Page 81 - Pharm.Org.Chem-I 02-06-05-101
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Enzyme-catalyzed organic reactions:
Lipase catalyzes hydrolysis of esters:
O
OEt
HF
O Ethyl (R)-(+)-2-fluorohexanoate
lipase (>99% enantiomeric excess)
+ +H O Et
OEt O
F H OH
Ethyl (+)-2-fluorohexanoate OH
[an ester that is a racemate FH
of (R) and (S) forms] (S)-(−)-2-Fluorohexanoic acid
(>69% enantiomeric excess)
157
158
79
