Page 133 - Biochemistry PharmD General
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Uses of NADPH
1. Reductive biosynthesis
NADPH is a high energy molecule and electron donor. It is
required as a source of electrons for biosynthesis of FA,
cholesterol, sterols, hormones, and bile salts.
2. Rlipeiddusc–tiornepoefrfHus2iOon2: ROS-damage DNA, proteins, unsaturated
injuries, cancer, inflammatory diseases,
aging.
Enzymes that catalyze Antioxidant reactions
Glutathione peroxidase or GOD [using reduced Glutathione or
GSH which is active as antioxidant, present in most cells which
can detoxify H2O2 ].
Glutathione reductase or GR [regenerates GSH from oxidized
glutathione formed in the above reaction] using NADPH as a
source of electrons.
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