Page 136 - Biochemistry PharmD General
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G-6-PD deficiency
• Inherited disease-most common disease producing
enzyme abnormality in humans- X-linked.
• People with glucose 6-phosphate dehydrogenase
deficiency (7% of the world population).
• Hemolytic anemia due to inability to detoxify
oxidizing agents.
• ↓activity of G6-PD→↓NADPH [HMP]
→↓detoxification of FR & peroxides
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