Page 143 - Biochemistry PharmD General

Kinetics of fructose metabolism

– The rate of fructose metabolism is more rapid than
that of glucose because trioses formed from F-1-P
bypass two regulatory reactions of glycolysis.
Therefore, ingestion of large quantities of fructose
increases the production of acetyl-CoA (building block
of fatty acids & cholesterol) thus increasing the
synthesis of triglycerides & cholesterol, which leads to
hyperlipidemia.

– The transport of fructose into the cells is not insulin-

dependent, and fructokinase is not affected by the

deficiency of insulin; therefore, fructose is given

instead of glucose in diabetic patients. 142