Page 192 - Biochemistry PharmD General

Hypoglycemia

• Definition: Decrease of blood glucose levels below normal average
concentration (less than 45 mg/dl).

• Effects: cerebral dysfunction, coma and death.

• Mechanisms that correct hypoglycemia:

– Short term-regulation
• Alpha cells of langerhans release glucagon.
• Hypothalamic receptors stimulates secretion of epinephrine.

– Long-term regulation
• Secretion of anterior pituitary hormones.
– Growth hormone (insulin antagonists).
– ACTH: stimulate secretion of glucocorticoids which
activates gluconeogenesis.

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