Page 258 - Biochemistry PharmD General

Processing Amino Acid Carbon Skeletons

Transamination or Oxidative deamination both produce alpha-keto
acids. Degradation of these carbon skeletons may take several
different pathways:

•Amino acid C skeletons that degrade to form a Krebs cycle
intermediate can then be used to make glucose via gluconeogenesis.
These are called Glucogenic Amino Acids.

•Amino acid C skeletons that degrade to form acetyl CoA or
Acetoacetyl CoA can form fatty acids or ketone bodies. These are
called Ketogenic Amino Acids.

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