Page 294 - Biochemistry PharmD General

• In states of oxidative stress, all remaining glutathione
is consumed. Enzymes and other proteins (including
hemoglobin) are subsequently damaged by the
oxidants, leading to electrolyte imbalance, membrane
cross-bonding and phagocytosis and splenic
sequestration of red blood cells.

• The hemoglobin is metabolized to bilirubin (causing
jaundice at high concentrations) or excreted directly
by the kidney (causing acute renal failure in severe
cases).

• Deficiency of G6PD in the alternative pathway causes
the build-up of glucose and thus there is an increase
of advanced glycation end products (AGE).

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