Page 295 - Biochemistry PharmD General

• The deficiency also causes a reduction of NADPH
which is necessary for the formation of Nitric Oxide
(NO). The high prevalence of diabetes mellitus type 2
and hypertension in Afro-Caribbean’s in the West
could be directly related to G6PD deficiency.

• Patients are almost exclusively male, due to the X-
linked pattern of inheritance, but female carriers can
be clinically affected due to lyonization where random
inactivation of an X-chromosome in certain cells
creates a population of G6PD deficient red cells
coexisting with normal red cells.

294