Page 334 - Biochemistry PharmD General
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Ketogenesis
-Ketogenesis is the conversion of long chain FA to the Four
carbon acetoacetate and 3 hydroxy butyrate (Ketone Bodies:
KB).
-The primary utility of ketogenesis is to provide a universally
accepted fuel for energy production ( an adaptive response in
starvation).
*The Brain oxidizes KB but not Fat.
*Other Tissues oxidize KB and Fat.
-Ketosis or Keto-Acidosis: A large accumulation of KB is
dangerous, because it leads to profound metabolic acidosis.
-The physiologic Ketogenesis of fasting and the adaptive ketosis in
starvation never progress to life threatening acidosis.
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