Page 338 - Biochemistry PharmD General
P. 338
The main factors which control
Ketogenesis in the liver
-Availability of the substrate (Long Chain Fatty Acids):
from increased production by lipolysis with increased
delivery of FA to the liver.
-The Glucagon/Insulin Ratio: a high ratio increases
lipolysis and activation of oxidative ketogenesis, a low
ratio counteracts ketogenesis.
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