Page 341 - Biochemistry PharmD General
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Ketone Bodies in Type 1 Diabetes
1.Insulin is deficient.
2. FFA and KB are increased, ketogenesis is activated
to provide energy source substitute. Delivery of FFA
substrate to the liver is not blocked (absence of the
blocking effect of insulin ).
3. KB Clearance is diminished.
4. An unrestricted KB accumulation leads to metabolic
acidosis (Diabetic Keto-acidosis )
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