Page 9 - Biochemistry PharmD General

How is metabolism regulated?

Fast mechanisms, for immediate changes

-Substrate concentration
-Allosteric regulation (feedback, feed forward)
(the regulation of an enzyme by binding an effector
molecule at a site other than the enzyme’s active site).
-Phosphorylation-dephosphorylation
-Signals emanating from hormone action

Slow mechanisms, for long-term changes

Genetic regulation
Response to diet and other environmental variables

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