Page 46 - controlled drug delievery

Cont. 3- Diffusion-Dissolution S.

Formulation of hydrophilic colloid matrix systems

1. Hydrophilic polymer e.g. Hydroxypropyl cellulose, Sodium

carboxymethyl cellulose, sodium alginate, xanthan gum, carbopol.

2. Matrix modifiers e.g. NaCl, sugars, polyols
3. Solubilizers & pH modifiers
4. Lubricant/glidant

The release rate from inert matrix can be modified by varying:

i. ii.
iii. iv.