Page 48 - controlled drug delievery

Cont.

4- Bioerodible /(Biodegradable) Systems.

• Bioerodible/biodegradable polymers
• E.g. Poly(lactic acid) (PLA)

Poly (lactic-co-glycolic acid) (PLGA)
Poly (anhydrides)
Poly (orthoesters) & Poly (phosphoesters)
• Polymer degradation rate is affected by:
• Polymer molecular weight
• Polymer hyrophilicity (the nature & ratio of building subunits)
• Polymer crystallinity

N.B. Toxicity of the degradation product should be identified