Page 16 - Dosage 1-part2 -ebook_Neat
P. 16
30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms
Three-dimensionally, CDs can be visualized as a hollow truncated cone.
The cavity in the cone has different diameters dependent on the number of glucose units in the
ring.
Drug inclusion within CDs effectively increases their aqueous solubility.
The interior cavity of CDs is hydrophobic, while their exterior is hydrophilic, therefore they
are soluble in water.
The –OH groups shown are actually attached to the top and bottom rims of the structure
and not to either the inside or outside walls.
The hydrophobic nature of the inside surface arises from the location of the –O–and C–H
bonds of the glucose molecules being orientated there.
The hydrophilic exterior results in CDs being soluble in water.
The less polar interior can accommodate non-polar drugs via non-covalent interactions
allowing them to be 'hidden', hence, to be molecularly dispersed in water.
Each cyclodextrin molecule can form complexes with one or more drug molecules
Upon administration, for example orally, of a solution containing a drug-CD complex, the drug
can be released from the CD and then be absorbed through the GIT.
file:///C:/Users/sara talaat/Downloads/solutions and sterile sols.HTML 13/77
