Page 241 - BIOCHEMISTRY II

Step 4: Conversion of
squalene to the four-
ring steroid nucleus
Squalene

monooxygenase adds

one oxygen atom from

O2 which forms

squalene-2,3-epoxide.

Linear squalene epoxide
can be converted into a
cyclical structure→
Lanosterol (in animal
cells)→ converted into
cholesterol in a series of
about 20 reactions