Page 130 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

D-alanyl-D-alanine residue altered to D-alanyl-D-lactate moiety.
vancomycin cannot bind to this peptide

III- Reduction of cellular permeability
- decreasing the uptake of the
antimicrobial molecule due to
Alteration of porins
(e.g. β-lactams, aminoglycosides,
quinolones)

IV- Efflux of Antibiotics

• Machineries capable of extruding drugs outside the cell

• Some organisms produce efflux pumps so increases overall capacity of
organism to eliminate drug

• Enables organism to resist higher concentrations of drug

117