Page 180 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Synergism Examples

1) Sequential inhibition of successive steps in metabolism

• e.g. sulphonamide- trimethoprim

• Treatment and prevention of chronic urinary tract infection, typhoid fever
and shigellosis.

2) Prevention of emergence of resistant populations

e.g. combination therapy for TB.

3) Inhibition of inactivating enzymes

e.g. Aminopenicillin/ -lactamase inhibitor combinations

Ampicillin-sulbactam, Amoxicillin-clavulanate

Extended-spectrum Penicillin/  -Lactamase inhibitor Combinations

Piperacillin-tazobactam, Ticarcillin-clavulanate.

• These compounds act as suicide inactivators of the bacterial beta- lactamases

enzymes

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