Page 7 - EADS Scientific Magazine .... 1st Edition

DNA The idea of genetic engineering has become more

exciting due to its advantages over other treatment mdal-

ities. The defective genes with their correct analogues to

produce functional proteins to regulate, repair, replace,

ehance or delete a genetic component.

Mechanisim of cleaved and insert- the target human cells

gene therapy ed into the genome results in releasing the
of a carrier or that is
Gene therapy is a usually an attenuated DNA sequence that
two-step process; in virus. In the second becomes integrated

the first step, human step the entry of within the chromo-
genetic coding for the modified vector to some.Gene transmis-

therapeutic protein is sion Application

Application of

gene therapy in

dentistry:

1. Orofacial pain: Gene

therapy is being investi-

gated for improving man-
agement of chronic pain encoding the human a combination of gene

,By production and secre- preproenkephalin gene therapy with other con-
tion of anti nociceptive through a herpes simplex ventional treatment mo-

proteins in or near spi- vector in a mouse model. dalities. Currently,
nal dorsal horns may be 2. Squamous cell carcino- there are more than 1000

achieved Today ,the use ma:. Gene therapy holds clinical trials of gene ther-

of therapy for alleviation the potential to give excit- apy in progress world-
is mainlyimited to animal ing treatment results and wide,

models as reduction in improved prognosis the
trigeminal pain has been response rate is higher in

reported patients receiving