Page 8 - EADS Scientific Magazine .... 1st Edition

3. Bone Repair: Gene 4. Orthodontic Tooth
therapy may represent an Movement:

ideal approach towards Gene therapy is done

augmenting by using the receptor
bone regeneration it can activator of the NF-kap-

enhance osteoinduction pa B (RANK) ligand, or
via expression RANKL. osteoprote-

of growth factors, induce gerin (OPG), which is
osteoblast , this osteocon- produced by osteoblas-

ductive tic

process makes them clin- cells or periodontal lig-
ically valuable as alterna- ament cells.the used of
tives to bone OPG and RANKL

grafts. While first con- accelerate and inhib-

ceived as a systemic treat- it orthodontic tooth
ment for movement in a rat

hereditary single-gene model.it is expected to
defects, localized gene use this effects not only

therapy is well for shortening
suited for bone formation orthodontic treatment,

because of the ability to but also for moving

deliver genes an-kylosed teeth where
to a discrete site. teeth fused to the sur-

rounding bone”.

REFRANCES:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030491/ https://pubmed.

ncbi.nlm.nih.gov/24188345/ Therapy for Tooth Regeneration by Stimu-

lation of a Third Dentition [PubMed] Encoding the Human Preproen-

kephalin Gene for Treatment of Facial Pain [PubMed] Gene therapy in the
management of oral cancer [PubMed