Page 83 - The prevalence of the Val66Met polymorphism in musicians: Possible evidence for compensatory neuroplasticity from a pilot study

6 | M. R. Zandoná et al. Genotype Genotype Genotype P-value P-corrected

Table 3 Associations of NEGR1, BDNF and TMEM18 polymorphisms with anthropometric parameters
ORIGINALRESEARCH NEGR1 rs2815752 Mean ± SD 305 Mean ± SD 306 49.2 ± 2.9 75 0.944 † † † 0.944
Phenotype
Mean ± SD
A/A
G/G
A/G
At birth
Length (cm)
49.0 ± 2.8
48.9 ± 2.8
0.944
306 3282 ± 597
75 0.848
3320 ± 525
Weight (g)
305 3314 ± 541
1 year
BMI Z-score
0.497
0.83 ± 1.09 295 0.63 ± 1.21 73 0.355
0.84 ± 1.14 291
3.5 years
§
0.68 ± 1.21 300
BMI Z-score
0.44 ± 1.13 306 0.57 ± 1.19 77 0.042
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Sum of skin-folds (mm)
14.5 ± 4.1
301
15.7 ± 5.9
0.098*
0.126
306 51.3 ± 4.0
51.2 ± 3.4
302
52.1 ± 5.9
76 0.072
Waist circumference (cm)
0.098*
73 0.030
BMI variation 1 year–3.5 years (%) || 7.2 ± 10.3 287 9.2 ± 8.5 304 14.3 ± 4.4 76 0.023 † † † † 0.098*
292 7.3 ± 8.4
BDNF rs6265 A-carriers G/G
At birth
Length (cm) 49.1 ± 2.8 200 49.0 ± 2.7 542 0.469 ‡ 0.656
Weight (g) 3309 ± 55 200 3301 ± 530 542 0.909 ‡ 0.909
1 year
BMI Z-score 0.64 ± 1.17 192 0.85 ± 1.11 521 0.026 ‡ 0.091*
3.5 years
BMI Z-score 0.48 ± 1.14 199 0.59 ± 1.18 538 0.330 ‡ 0.588
Sum of skin-folds (mm) 14.3 ± 4.3 196 15.4 ± 5.3 541 0.011 ‡ 0.077*
Waist circumference (cm) 51.3 ± 5.0 197 51.7 ± 4.7 544 0.336 ‡ 0.588
BMI variation 1 year–3.5 years (%) 7.6 ± 9.7 190 7.9 ± 9.3 514 0.580 ‡ 0.676
BDNF rs10767664 T-carriers A/A
At birth
Length (cm) 49.1 ± 2.8 213 49.0 ± 2.7 522 0.692 ‡ 0.884
Weight (g) 3304 ± 538 213 3303 ± 536 522 0.884 ‡ 0.884
1 year
BMI Z-score 0.68 ± 1.17 205 0.84 ± 1.10 501 0.082 ‡ 0.287
3.5 years
BMI Z-score 0.44 ± 1.10 212 0.61 ± 1.20 519 0.167 ‡ 0.389
Sum of skin-folds (mm) 14.2 ± 4.0 208 15.4 ± 5.4 522 0.009 ‡ 0.063*
Waist circumference (cm) 51.3 ± 4.9 209 51.8 ± 4.8 524 0.262 ‡ 0.458
BMI variation 1 year–3.5 years old (%) 8.1 ± 9.6 203 7.6 ± 9.5 495 0.770 ‡ 0.884
TMEM18 rs6548238 T-carriers C/C
At birth
Length (cm) 49.1 ± 2.9 189 49.0 ± 2.7 556 0.477 ‡ 0.552
Weight (g) 3286 ± 540 189 3311 ± 531 556 0.552 ‡ 0.552
1 year
BMI Z-score 0.67 ± 1.03 180 0.83 ± 1.15 534 0.099 ‡ 0.259
3.5 years
BMI Z-score 0.33 ± 1.16 188 0.65 ± 1.18 552 0.007 ‡ 0.049*
Sum of skin-folds (mm) 14.7 ± 4.6 187 15.2 ± 5.2 551 0.363 ‡ 0.508
Waist circumference (cm) 51.1 ± 5.1 187 51.8 ± 4.6 555 0.111 ‡ 0.259
BMI variation 1 year–3.5 years (%) 8.7 ± 8.5 177 7.4 ± 9.8 528 0.153 ‡ 0.268
Data are presented as mean ± standard deviation. Variables were adjusted by gender, cohort and intervention group.
Statistical test performed with sum of skin-folds variable ln-transformed.*Significant corrected P-values according to Benjamini–Hochberg method with the
¶
§
†
‡
false discovery rate of 0.10. One-way ANOVA . Student’s T-test. Tukey test A/A × A/G P = 0.052, A/A × G/G P = 0.723, A/G × G/G P = 0.753. Tukey test A/
||
A × A/G P = 0.060, A/A × G/G P = 0.071, A/G × G/G P = 0.726. Tukey test A/A × A/G P = 0.031, A/A × G/G P = 0.999, A/G × G/G P = 0.262.
© 2016 World Obesity. Pediatric Obesity ••, ••–••