Page 15 - 2014 Printable Abstract Book
P. 15
TR1. RADIONUCLIDES- THE RODNEY DANGERFIELD OF RADIATION DOSIMETRY AND BIOLOGY
(TR101) Radionuclides - the Rodney Dangerfield of radiation dosimetry and biology. Raymond A.
Guilmette, PhD, Ray Guilmette and Associates LLC, Perry, ME
There are many important differences between exposures resulting from external sources of
radiation and exposures due to intakes of radionuclides. These differences require that different
approaches for measuring and calculating radiation doses for these two exposure modalities be
considered. Additionally the biological responses to exposures from external and internal radiation have
been shown to be different, sometimes significantly. These differences can be attributed to differences in
spatial and temporal radiation dose patterns as well as involvement of different types of radiations (alpha,
beta, gamma, X ray, protons, neutrons etc.). Most radiation researchers and radiation protection
professionals are experienced with external radiation sources, and sometimes do not appreciate the
important differences between them. The purpose of this presentation is to describe the differences in
dosimetry as applied to external and internal exposure, the approaches used to deal with spatial and
temporal heterogeneity in dose, and the different biological effects that are observed with radionuclide
exposures compared with those occurring with brief external irradiation. Finally, some insight into
methods of managing exposures to intakes of radionuclides will be provided. The goal is to provide the
attendee with a better appreciation and understanding of the important differences between external
and internal radiation exposure scenarios.
TR2. DESKTOP MICROBEAMS AND RADIATION THERAPY
(TR201) Desktop Microbeams and Radiation Therapy. Yueh Lee, University of North Carolina School of
Medicine, Capitol Hill, NC
Radiation therapy is a key component in the treatment of tumors. However, radiation dose limits
in radiosensitive organs limits its effectiveness. Microbeam radiation therapy (MRT), has been shown to
selectively eradicate tumors with minimal damage to the normal tissue in early animal studies. A spatially
distinct set of linear Microbeams of radiation is applied to the tumor at doses significantly higher than
conventional radiotherapy. The mechanisms remain poorly understood. To date, all MRT studies have
been performed at the national synchrotron laboratories due to the availability of high intensity radiation.
This severely limits the potential for other biomedical research groups to evaluate the mechanisms driving
the MRT treatment advantages. We have developed the first desktop MRT device based on our carbon
nanotube x-ray technology. Our MRT device uses multiple concurrently activated x-ray sources placed in
close proximity to significantly increase microbeam dose delivery rates. We will review the history and
present work on microbeam radiotherapy and the current and future capabilities of our desktop
radiotherapy system.
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(TR101) Radionuclides - the Rodney Dangerfield of radiation dosimetry and biology. Raymond A.
Guilmette, PhD, Ray Guilmette and Associates LLC, Perry, ME
There are many important differences between exposures resulting from external sources of
radiation and exposures due to intakes of radionuclides. These differences require that different
approaches for measuring and calculating radiation doses for these two exposure modalities be
considered. Additionally the biological responses to exposures from external and internal radiation have
been shown to be different, sometimes significantly. These differences can be attributed to differences in
spatial and temporal radiation dose patterns as well as involvement of different types of radiations (alpha,
beta, gamma, X ray, protons, neutrons etc.). Most radiation researchers and radiation protection
professionals are experienced with external radiation sources, and sometimes do not appreciate the
important differences between them. The purpose of this presentation is to describe the differences in
dosimetry as applied to external and internal exposure, the approaches used to deal with spatial and
temporal heterogeneity in dose, and the different biological effects that are observed with radionuclide
exposures compared with those occurring with brief external irradiation. Finally, some insight into
methods of managing exposures to intakes of radionuclides will be provided. The goal is to provide the
attendee with a better appreciation and understanding of the important differences between external
and internal radiation exposure scenarios.
TR2. DESKTOP MICROBEAMS AND RADIATION THERAPY
(TR201) Desktop Microbeams and Radiation Therapy. Yueh Lee, University of North Carolina School of
Medicine, Capitol Hill, NC
Radiation therapy is a key component in the treatment of tumors. However, radiation dose limits
in radiosensitive organs limits its effectiveness. Microbeam radiation therapy (MRT), has been shown to
selectively eradicate tumors with minimal damage to the normal tissue in early animal studies. A spatially
distinct set of linear Microbeams of radiation is applied to the tumor at doses significantly higher than
conventional radiotherapy. The mechanisms remain poorly understood. To date, all MRT studies have
been performed at the national synchrotron laboratories due to the availability of high intensity radiation.
This severely limits the potential for other biomedical research groups to evaluate the mechanisms driving
the MRT treatment advantages. We have developed the first desktop MRT device based on our carbon
nanotube x-ray technology. Our MRT device uses multiple concurrently activated x-ray sources placed in
close proximity to significantly increase microbeam dose delivery rates. We will review the history and
present work on microbeam radiotherapy and the current and future capabilities of our desktop
radiotherapy system.
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