Page 20 - 2014 Printable Abstract Book
P. 20
TR10. ADVANCES IN APPLCIATIONS AND BIOLOGICAL UNDERSTANDING OF ABLATIVE THERAPIES
ALONE AND COMBINED WITH CONVENTION RT
(TR1001) Advances in applications and biological understanding of ablative therapies alone and
2
2
1
combined with conventional RT. Robert J. Griffin , Chang W. Song ; John C. Bischof ; Matthew E.
1
1
1
Hardee ; Jose A. Penagaricano ; and Jose A. Penagaricano University of Arkansas for Med Sci, Little
Rock, AR and University of Minnesota, Minneapolis, MN
2
1
There are now multiple approaches for thermal ablation of primary and metastatic/recurrent
tumors being taken in centers all over the world. Thermal ablation offers the ease of a single treatment,
reduction or elimination of the majority of the tumor mass and little to no evidence of resistance to
repeated therapy. However, much of the use of these approaches occur in the interventional radiology
setting and few complete clinical trials have been performed due to variances in equipment used,
operator tendencies, tumor sites chosen for treatment and other considerations. As such, recurrences or
incomplete treatments remain a problem in many settings. Therefore, many are looking to understand
the possible benefits of combined treatments and technologies to offer a more complete
tumor treatment. Tumor tissue in the margin that is sublethally ablated releases factors in an attempt to
attract cells to repair and regrow the tumor, many times via an angiogenic /vasculogenic activation which
also leads to changes in perfusion and oxygenation. Blood supply and oxygenation changes in tumor that
remains viable after ablation may alter the effect of concomitant application of chemotherapy or radiation
therapy. This topical review will demonstrate the various ablative modalities being employed in oncology
such as HIFU, RF, microwave and cryosurgery and the envisioned potential for combination with
radiotherapy. The field of radiation ablation via SBRT and microbeam radiotherapy will also be discussed
in the broader context of options for lower treatment number, higher tumor effect treatment strategies
available today. In work from our laboratory, we have determined that ablation can be performed before
or after hypofractionatied radiotherapy to improve tumor control, however, radiotherapy applied first is
clinically most feasible. We have also implemented multi-modal imaging to identify and target and ablate
hypoxic regions of a tumor using PET/MRI before subsequent radiation therapy. Ongoing efforts are to
characterize the tumor hypoxia and apply HIFU ablation to these regions to reduce radioresistance and
assess thera-peutic potential of this tailored approach. Supported by NIH CA44114 and CA44114S and
grants from the Focused Ultrasound Surgery Foundation and the Arkansas Breast Cancer Research
Program.
TR11. THE LEPTIN MODULATION IN RESPONSE TO IRRADIATION: TIME TO MOVE FROM CELL TO
TISSUES INTERPLAY
(TR1101) The Leptin modulation in response to irradiation: time to move from cell to tissues interplay.
Roberto Amendola, ENEA, Rome, Italy
Biological effects related to ionizing radiations still constitute an essential challenge since many
uncertainties still are unveiled. Many different cellular structures, processes and functions concur in
radiation syndrome, included alterations of cell-cell crosstalk and cell-matrix interactions, suggesting that
the responses of cell signaling to radiations is not related solely to DNA damage. A meta-analysis of a
transcriptomic dataset referring to 202 different irradiation conditions identified a set of genes which
18 | P a g e
ALONE AND COMBINED WITH CONVENTION RT
(TR1001) Advances in applications and biological understanding of ablative therapies alone and
2
2
1
combined with conventional RT. Robert J. Griffin , Chang W. Song ; John C. Bischof ; Matthew E.
1
1
1
Hardee ; Jose A. Penagaricano ; and Jose A. Penagaricano University of Arkansas for Med Sci, Little
Rock, AR and University of Minnesota, Minneapolis, MN
2
1
There are now multiple approaches for thermal ablation of primary and metastatic/recurrent
tumors being taken in centers all over the world. Thermal ablation offers the ease of a single treatment,
reduction or elimination of the majority of the tumor mass and little to no evidence of resistance to
repeated therapy. However, much of the use of these approaches occur in the interventional radiology
setting and few complete clinical trials have been performed due to variances in equipment used,
operator tendencies, tumor sites chosen for treatment and other considerations. As such, recurrences or
incomplete treatments remain a problem in many settings. Therefore, many are looking to understand
the possible benefits of combined treatments and technologies to offer a more complete
tumor treatment. Tumor tissue in the margin that is sublethally ablated releases factors in an attempt to
attract cells to repair and regrow the tumor, many times via an angiogenic /vasculogenic activation which
also leads to changes in perfusion and oxygenation. Blood supply and oxygenation changes in tumor that
remains viable after ablation may alter the effect of concomitant application of chemotherapy or radiation
therapy. This topical review will demonstrate the various ablative modalities being employed in oncology
such as HIFU, RF, microwave and cryosurgery and the envisioned potential for combination with
radiotherapy. The field of radiation ablation via SBRT and microbeam radiotherapy will also be discussed
in the broader context of options for lower treatment number, higher tumor effect treatment strategies
available today. In work from our laboratory, we have determined that ablation can be performed before
or after hypofractionatied radiotherapy to improve tumor control, however, radiotherapy applied first is
clinically most feasible. We have also implemented multi-modal imaging to identify and target and ablate
hypoxic regions of a tumor using PET/MRI before subsequent radiation therapy. Ongoing efforts are to
characterize the tumor hypoxia and apply HIFU ablation to these regions to reduce radioresistance and
assess thera-peutic potential of this tailored approach. Supported by NIH CA44114 and CA44114S and
grants from the Focused Ultrasound Surgery Foundation and the Arkansas Breast Cancer Research
Program.
TR11. THE LEPTIN MODULATION IN RESPONSE TO IRRADIATION: TIME TO MOVE FROM CELL TO
TISSUES INTERPLAY
(TR1101) The Leptin modulation in response to irradiation: time to move from cell to tissues interplay.
Roberto Amendola, ENEA, Rome, Italy
Biological effects related to ionizing radiations still constitute an essential challenge since many
uncertainties still are unveiled. Many different cellular structures, processes and functions concur in
radiation syndrome, included alterations of cell-cell crosstalk and cell-matrix interactions, suggesting that
the responses of cell signaling to radiations is not related solely to DNA damage. A meta-analysis of a
transcriptomic dataset referring to 202 different irradiation conditions identified a set of genes which
18 | P a g e
