Page 352 - 2014 Printable Abstract Book
P. 352
structure. Radiation exposure was confirmed using real-time dosimetry and NanoDot dosimeters placed
in the shielded area. Acidified water, wetted chow and water gel packs were provided as supportive care.
Survival was assessed over a period of 230 days following irradiation. Between Days 60-65, 120-125 and
180-185, lungs damage and changes in respiratory function were evaluated using CT-scan imaging and
head-out plethysmography. Results: Delayed mortalities were generally observed from Day 131 to Day
186 post-irradiation, yielding to LD95 and LD100 at 15.25 and 16 Gy, respectively. Between Days 60 and
125, CT-scan imaging revealed a trend towards mild interstitial lung pattern in some irradiated animals.
Between Days 180 and 185, a diffuse pattern of increased radio-opacity with limited expansion of the
lungs was noted in irradiated mice suggesting a restrictive lung disorder with fibrosis. Although respiratory
rate and minute ventilation were not significantly changed, lower tidal volume was consistently noted on
Days 180-185 in irradiated mice compared to sham animals, further supporting the presence of pulmonary
injury. Conclusion: Late effects of radiation including lung damage and alteration of the respiratory
function were observed in the current rodent model of partial body irradiation, which may serve in
development of drugs as radiation countermeasures.
350 | P a g e
in the shielded area. Acidified water, wetted chow and water gel packs were provided as supportive care.
Survival was assessed over a period of 230 days following irradiation. Between Days 60-65, 120-125 and
180-185, lungs damage and changes in respiratory function were evaluated using CT-scan imaging and
head-out plethysmography. Results: Delayed mortalities were generally observed from Day 131 to Day
186 post-irradiation, yielding to LD95 and LD100 at 15.25 and 16 Gy, respectively. Between Days 60 and
125, CT-scan imaging revealed a trend towards mild interstitial lung pattern in some irradiated animals.
Between Days 180 and 185, a diffuse pattern of increased radio-opacity with limited expansion of the
lungs was noted in irradiated mice suggesting a restrictive lung disorder with fibrosis. Although respiratory
rate and minute ventilation were not significantly changed, lower tidal volume was consistently noted on
Days 180-185 in irradiated mice compared to sham animals, further supporting the presence of pulmonary
injury. Conclusion: Late effects of radiation including lung damage and alteration of the respiratory
function were observed in the current rodent model of partial body irradiation, which may serve in
development of drugs as radiation countermeasures.
350 | P a g e
