Page 424 - 2014 Printable Abstract Book
P. 424
(PS7-78) French cohort of uranium-enrichment workers: first results of mortality analysis. Sergey
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Zhivin ; Irina Guseva Canu ; Eric Samson ; Olivier Laurent ; Philippe Collomb ; and Dominique Laurier
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Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France ; Institut de Veille
Sanitaire, Saint-Maurice, France ; and AREVA NC Occupational Health Department, Pierrelatte, France
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Background: Physicochemical characteristics of radionuclides, such as solubility, influence their
biokinetics and potential health effects. During uranium enrichment, exposure to predominantly soluble
uranium compounds may occur. A retrospective cohort of French uranium-enrichment workers was set
up to study their mortality and relationship with internal exposure to soluble uranium and external
radiation exposure. Materials & Methods: The cohort includes all workers involved in uranium enrichment
production for military and civil purposes at Pierrelatte (France), and employed for at least 6 months
between 1964 and 2006. Standardized mortality ratios (SMR) were computed using national mortality
rates available for the period 1968-2008. Individual internal uranium exposure was assessed using plant-
specific job-exposure matrixes that differentiate uranium compounds by their isotopic composition and
solubility. Results: The cohort includes 4,712 workers. Mean follow-up duration is 31 years; and mean age
at the end of follow-up is 63 years. Twenty-one percent of workers deceased, with causes of death known
for 99% of deaths. The SMR analysis reflects an important healthy worker effect (all-cause SMR=0.68,
95%CI=0.64 to 0.72, n=1,013; all-cancer SMR=0.87 95%CI=0.79 to 0.96, n=431). In total 3,996 workers
were potentially exposed to uranium. Analysis of mortality risk according to external gamma-radiation
dose and internal uranium exposure is ongoing. Conclusion: This cohort has several advantages: a good
follow-up quality, stable homogeneous study population and availability of individual exposure data. It
should provide new results on the association between exposure to soluble uranium and health effects in
human population.
(PS7-79) E-ANDANTE project: second cancers from neutrons following proton therapy: preliminary
epidemiological studies. Katrin Perstorfer, MSc and Linda Walsh, PhD, DSc; Federal Office for Radiation
Protection, Neuherberg, Germany
Survivors of childhood cancer have an increased risk of developing secondary cancers after the
treatment for the first primary cancer. Proton therapy represents an effective treatment technique for
some types of childhood cancers but scattered radiation from secondary neutrons is an unwanted by-
product. The neutron doses to organs both in and outside the treatment volume increase the risk of
developing a secondary cancer. To investigate the secondary cancer risk specifically from neutrons, the
ANDANTE project involves two epidemiological aspects: conducting a literature review to provide basic
information required in the development of neutron risk models; and assessing the feasibility of setting
up a prospective epidemiological study on secondary cancers from neutrons after proton therapy during
childhood. A systematic review of 45 epidemiological studies on second malignant solid neoplasms (SMN)
occurring after radiotherapy in childhood from 2001 to 2013 was conducted. Detailed data was extracted
on patient characteristics and radiation therapy that included the sites of first malignant neoplasm and
SMN and dose delivered to tumor/other organs amongst others. The extracted data will be applied to
perform a meta-analysis, followed by a subgroup-analysis with regard to the local occurrence of the SMN
is in or out of the original treatment field after developing a set of criteria to estimate the SMN location
and in/out of field characteristics. Special emphasis will be placed on the SMN sites of breast, thyroid, and
1
1
2
1
3
1
Zhivin ; Irina Guseva Canu ; Eric Samson ; Olivier Laurent ; Philippe Collomb ; and Dominique Laurier
1
Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France ; Institut de Veille
Sanitaire, Saint-Maurice, France ; and AREVA NC Occupational Health Department, Pierrelatte, France
3
2
Background: Physicochemical characteristics of radionuclides, such as solubility, influence their
biokinetics and potential health effects. During uranium enrichment, exposure to predominantly soluble
uranium compounds may occur. A retrospective cohort of French uranium-enrichment workers was set
up to study their mortality and relationship with internal exposure to soluble uranium and external
radiation exposure. Materials & Methods: The cohort includes all workers involved in uranium enrichment
production for military and civil purposes at Pierrelatte (France), and employed for at least 6 months
between 1964 and 2006. Standardized mortality ratios (SMR) were computed using national mortality
rates available for the period 1968-2008. Individual internal uranium exposure was assessed using plant-
specific job-exposure matrixes that differentiate uranium compounds by their isotopic composition and
solubility. Results: The cohort includes 4,712 workers. Mean follow-up duration is 31 years; and mean age
at the end of follow-up is 63 years. Twenty-one percent of workers deceased, with causes of death known
for 99% of deaths. The SMR analysis reflects an important healthy worker effect (all-cause SMR=0.68,
95%CI=0.64 to 0.72, n=1,013; all-cancer SMR=0.87 95%CI=0.79 to 0.96, n=431). In total 3,996 workers
were potentially exposed to uranium. Analysis of mortality risk according to external gamma-radiation
dose and internal uranium exposure is ongoing. Conclusion: This cohort has several advantages: a good
follow-up quality, stable homogeneous study population and availability of individual exposure data. It
should provide new results on the association between exposure to soluble uranium and health effects in
human population.
(PS7-79) E-ANDANTE project: second cancers from neutrons following proton therapy: preliminary
epidemiological studies. Katrin Perstorfer, MSc and Linda Walsh, PhD, DSc; Federal Office for Radiation
Protection, Neuherberg, Germany
Survivors of childhood cancer have an increased risk of developing secondary cancers after the
treatment for the first primary cancer. Proton therapy represents an effective treatment technique for
some types of childhood cancers but scattered radiation from secondary neutrons is an unwanted by-
product. The neutron doses to organs both in and outside the treatment volume increase the risk of
developing a secondary cancer. To investigate the secondary cancer risk specifically from neutrons, the
ANDANTE project involves two epidemiological aspects: conducting a literature review to provide basic
information required in the development of neutron risk models; and assessing the feasibility of setting
up a prospective epidemiological study on secondary cancers from neutrons after proton therapy during
childhood. A systematic review of 45 epidemiological studies on second malignant solid neoplasms (SMN)
occurring after radiotherapy in childhood from 2001 to 2013 was conducted. Detailed data was extracted
on patient characteristics and radiation therapy that included the sites of first malignant neoplasm and
SMN and dose delivered to tumor/other organs amongst others. The extracted data will be applied to
perform a meta-analysis, followed by a subgroup-analysis with regard to the local occurrence of the SMN
is in or out of the original treatment field after developing a set of criteria to estimate the SMN location
and in/out of field characteristics. Special emphasis will be placed on the SMN sites of breast, thyroid, and
