Page 425 - 2014 Printable Abstract Book
P. 425
salivary gland tumors as these will eventually be relevant for estimating the neutron risks after completion
of the characterization of neutron fields in other ANDANTE tasks. Moreover, a feasibility study with clinical
data from the Loma Linda Medical Centre (Loma Linda, California, USA) on pediatric patients with
arteriovenous malformations (AVM) and astrocytomas (grade I & II) will be performed with regard to
setting up a proposal for a prospective epidemiological study. All important variables for statistical
analyses are available and are currently being collected. The results will provide a basis for the
development of the prospective epidemiological study, and will be used to test the validity of a predictive
risk model based on values of neutron RBE from the physics task in the ANDANTE project.
(PS7-80) Risk of cancer associated with cardiac catheterization procedures during childhood: the
1
1
2
1
1
COCCINELLE study. Neige Journy ; Hélène Baysson ; Sérine Barnaoui ; Jean-Luc Réhel ; Brigitte Girodon ;
2
1
2
1
1
Younès Boudjemline ; Bernard Aubert ; Dominique Laurier ; Damien Bonnet ; and Marie-Odile Bernier ,
1
IRSN, Fontenay-aux-Roses, France and Centre de Référence Malformations Cardiaques Congénitales
Complexes, Hôpital Necker-Enfants Malades, Paris, France
2
Introduction - Children with congenital heart disease frequently undergo interventional
cardiology (IC) procedures for diagnostic or therapeutic purposes. Despite the clear clinical benefit to the
patient, the complexity of these procedures may result in high cumulative radiation exposure. Given
children's greater sensitivity to radiation and the longer life span during which radiation health effects can
develop, an epidemiological cohort study, named Coccinelle, is carried out in France to evaluate the risks
of leukemia and solid cancers in this population. In this context, precise retrospective evaluation of doses
received by the children during paediatric IC is needed. Methods - All children who have undergone at
least one IC procedure since 2000 and were under 10 years old will be included. The study is expected to
finally include a total of 8000 children. Electronically stored patient records from the departments of
paediatric cardiology of the French national network for complex congenital heart diseases (M3C) are
being searched to identify the children to be included. The main procedures investigated are: Diagnostic,
Patent Ductus Arterious closure, Atrial Septal Defects closure, balloon valvuloplasty, balloon angioplasty
and electrophysiology procedures. For each procedure, dosimetric parameters (dose area product,
fluoroscopy time and total number of cine frames) are retrieved retrospectively. Organ doses are
calculated with PCXMC software. Results - Up to now, 4500 children have been already included in the
cohort but recruitment is still ongoing. On average, each child has undergone 1.3 cardiac catheterization
procedure, for a total of over 5,000 procedures. Nearly half of these were performed during the first year
of life. Dosimetric data were analyzed for 801 IC procedures performed between 2010 and 2011. For
diagnostic procedures, the mean effective dose value was 4.8 mSv (min: 0.3 mSv: max: 23 mSv). For
therapeutic procedures, the mean effective dose value was 7.3 mSv (min: 0.1 mSv; max: 48.4 mSv).
Whatever the procedure was, the highest organ doses were found for the lungs and oesophagus.
Conclusions - The increasing use of IC in paediatric population stresses the need of setting up reference
levels and keeping doses to children as low as possible.
of the characterization of neutron fields in other ANDANTE tasks. Moreover, a feasibility study with clinical
data from the Loma Linda Medical Centre (Loma Linda, California, USA) on pediatric patients with
arteriovenous malformations (AVM) and astrocytomas (grade I & II) will be performed with regard to
setting up a proposal for a prospective epidemiological study. All important variables for statistical
analyses are available and are currently being collected. The results will provide a basis for the
development of the prospective epidemiological study, and will be used to test the validity of a predictive
risk model based on values of neutron RBE from the physics task in the ANDANTE project.
(PS7-80) Risk of cancer associated with cardiac catheterization procedures during childhood: the
1
1
2
1
1
COCCINELLE study. Neige Journy ; Hélène Baysson ; Sérine Barnaoui ; Jean-Luc Réhel ; Brigitte Girodon ;
2
1
2
1
1
Younès Boudjemline ; Bernard Aubert ; Dominique Laurier ; Damien Bonnet ; and Marie-Odile Bernier ,
1
IRSN, Fontenay-aux-Roses, France and Centre de Référence Malformations Cardiaques Congénitales
Complexes, Hôpital Necker-Enfants Malades, Paris, France
2
Introduction - Children with congenital heart disease frequently undergo interventional
cardiology (IC) procedures for diagnostic or therapeutic purposes. Despite the clear clinical benefit to the
patient, the complexity of these procedures may result in high cumulative radiation exposure. Given
children's greater sensitivity to radiation and the longer life span during which radiation health effects can
develop, an epidemiological cohort study, named Coccinelle, is carried out in France to evaluate the risks
of leukemia and solid cancers in this population. In this context, precise retrospective evaluation of doses
received by the children during paediatric IC is needed. Methods - All children who have undergone at
least one IC procedure since 2000 and were under 10 years old will be included. The study is expected to
finally include a total of 8000 children. Electronically stored patient records from the departments of
paediatric cardiology of the French national network for complex congenital heart diseases (M3C) are
being searched to identify the children to be included. The main procedures investigated are: Diagnostic,
Patent Ductus Arterious closure, Atrial Septal Defects closure, balloon valvuloplasty, balloon angioplasty
and electrophysiology procedures. For each procedure, dosimetric parameters (dose area product,
fluoroscopy time and total number of cine frames) are retrieved retrospectively. Organ doses are
calculated with PCXMC software. Results - Up to now, 4500 children have been already included in the
cohort but recruitment is still ongoing. On average, each child has undergone 1.3 cardiac catheterization
procedure, for a total of over 5,000 procedures. Nearly half of these were performed during the first year
of life. Dosimetric data were analyzed for 801 IC procedures performed between 2010 and 2011. For
diagnostic procedures, the mean effective dose value was 4.8 mSv (min: 0.3 mSv: max: 23 mSv). For
therapeutic procedures, the mean effective dose value was 7.3 mSv (min: 0.1 mSv; max: 48.4 mSv).
Whatever the procedure was, the highest organ doses were found for the lungs and oesophagus.
Conclusions - The increasing use of IC in paediatric population stresses the need of setting up reference
levels and keeping doses to children as low as possible.
