Page 50 - 2014 Printable Abstract Book
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gross tumor volume of hypoxic tumors or specifically just to the hypoxic sub-volumes that are identified
from non-invasive hypoxia imaging. Alternatively, one could use radiation with a higher linear energy
transfer, where hypoxic resistance is less of an issue. This presentation will review the various approaches
used to target hypoxia and focus on the current status and suggest which method(s) have the greatest
potential to improve local tumor control and overall survival in those patients receiving curative radiation
therapy. Supported by grants from the Danish Cancer Society and the Danish Agency for Science
Technology & Innovation.
S09 THERE IS LIFE IN THE OLD DOG YET: RADIOBIOLOGICAL ARCHIVES 2014
Large scale animal studies concluded before the "omics" era. However, some original tissue/slide archives
exist, and are amenable to genomic and proteomic analysis. Preserved human tissue archives may be an
even greater resource for future study. We will explore current studies and new technologies that show
there is life in the old dog (archives) yet.
(S901) Biological Resources of the Radiation Effects Research Foundation_Issues to be resolved
regarding their future use. Kazunori Kodama, Radiation Effects Research Foundation, Hiroshima, Japan
In my presentation I will review the issues that need to be resolved with regard to future use of
the biological samples that have been stored over a period of several decades by the Atomic Bomb
Casualty Commission (ABCC) and its successor, the Radiation Effects Research Foundation (RERF).
As a unique resource with which to study the long-term health effects in the atomic-bomb survivors, a
cohort of about 120,000 members has been followed in the Life Span Study (LSS) for mortality and cancer
incidence. A subset of the LSS, the Adult Health Study, with about 15,000 participants, has been
undergoing additional morbidity surveillance based on biennial health examinations. Similarly, follow-up
studies for mortality, cancer incidence, and morbidity in the offspring of atomic bomb survivors have been
conducted over many years. Such biological samples collected by the ABCC/RERF follow-up studies from
individuals within various cohorts over extended timeframes include serum, plasma, urine, lymphocytes,
paraffin-embedded tissues, as well as teeth. In April 2013, the Biosample Center was established at RERF
with the aim of appropriate safekeeping and use of these valuable biological samples stored at RERF. The
major tasks of the center include centralized management of archival samples, risk management related
to the storage and use of the samples, introduction of appropriate storage methods, database creation,
and establishment of systemized standards for use of the biological samples both within and outside of
the foundation. With regard to use of the samples in future collaborative studies with outside
investigators, many important steps need to be taken that include the resolution of ethical issues, and the
acquisition of understanding and support from atomic-bomb survivors and the local communities of
Hiroshima and Nagasaki. The biological samples are a valuable resource for biochemical and mechanistic
laboratory studies, making possible a wide range of studies to elucidate radiation-associated disease
mechanisms using new technologies.
48 | P a g e
from non-invasive hypoxia imaging. Alternatively, one could use radiation with a higher linear energy
transfer, where hypoxic resistance is less of an issue. This presentation will review the various approaches
used to target hypoxia and focus on the current status and suggest which method(s) have the greatest
potential to improve local tumor control and overall survival in those patients receiving curative radiation
therapy. Supported by grants from the Danish Cancer Society and the Danish Agency for Science
Technology & Innovation.
S09 THERE IS LIFE IN THE OLD DOG YET: RADIOBIOLOGICAL ARCHIVES 2014
Large scale animal studies concluded before the "omics" era. However, some original tissue/slide archives
exist, and are amenable to genomic and proteomic analysis. Preserved human tissue archives may be an
even greater resource for future study. We will explore current studies and new technologies that show
there is life in the old dog (archives) yet.
(S901) Biological Resources of the Radiation Effects Research Foundation_Issues to be resolved
regarding their future use. Kazunori Kodama, Radiation Effects Research Foundation, Hiroshima, Japan
In my presentation I will review the issues that need to be resolved with regard to future use of
the biological samples that have been stored over a period of several decades by the Atomic Bomb
Casualty Commission (ABCC) and its successor, the Radiation Effects Research Foundation (RERF).
As a unique resource with which to study the long-term health effects in the atomic-bomb survivors, a
cohort of about 120,000 members has been followed in the Life Span Study (LSS) for mortality and cancer
incidence. A subset of the LSS, the Adult Health Study, with about 15,000 participants, has been
undergoing additional morbidity surveillance based on biennial health examinations. Similarly, follow-up
studies for mortality, cancer incidence, and morbidity in the offspring of atomic bomb survivors have been
conducted over many years. Such biological samples collected by the ABCC/RERF follow-up studies from
individuals within various cohorts over extended timeframes include serum, plasma, urine, lymphocytes,
paraffin-embedded tissues, as well as teeth. In April 2013, the Biosample Center was established at RERF
with the aim of appropriate safekeeping and use of these valuable biological samples stored at RERF. The
major tasks of the center include centralized management of archival samples, risk management related
to the storage and use of the samples, introduction of appropriate storage methods, database creation,
and establishment of systemized standards for use of the biological samples both within and outside of
the foundation. With regard to use of the samples in future collaborative studies with outside
investigators, many important steps need to be taken that include the resolution of ethical issues, and the
acquisition of understanding and support from atomic-bomb survivors and the local communities of
Hiroshima and Nagasaki. The biological samples are a valuable resource for biochemical and mechanistic
laboratory studies, making possible a wide range of studies to elucidate radiation-associated disease
mechanisms using new technologies.
48 | P a g e
