Page 51 - 2014 Printable Abstract Book
P. 51
1
1
1
(S902) Continuous exploration of JANUS archives. Tatjana Paunesku ; Benjamin M. Haley ; William Liu ;
2
1
1
1
Sumita Raha ; Beau M. Wanzer ; Lydia Finney ; and Gayle E. Woloschak, Northwestern University,
2
Chicago, IL and Advanced Photon Source, Argonne, IL
1
During the cold war era thousands of animals in US were exposed to radiation at different doses
and dose rates of radiation matching radiation qualities expected from a nuclear catastrophe. While
contemporary interests in radiation have shifted to types of exposures expected from therapeutic
radiation or space radiation, almost no new animal experiments are conducted where irradiated model
organisms are allowed to live out their natural lifespan after irradiation treatment. Radiobiological
archives still provide the only source of lifetime data on hundreds and thousands of irradiated mice, rats
and dogs. Our laboratory has collected both data and animal materials from these historic irradiation
experiments and continues to explore both with new computational and biotechnological tools.
(S903) The National Human Radiobiological Tissue Repository: a unique resource for scientists.
Sergei Tolmachev, Washington State University, Pullman, WA
The United States Transuranium and Uranium Registries (USTUR), and the associated National
Human Radiobiology Tissue Repository (NHRTR), is a federal-grant program funded by U.S. Department
of Energy and operated by College of Pharmacy at Washington State University in Richland, WA. The
USTUR studies the biokinetics and internal dosimetry of actinides (uranium, thorium, plutonium, and
americium) in occupationally exposed individuals who volunteer their bodies (partially or entirely) for
scientific use posthumously. A portion of the tissues received by the USTUR is radiochemically analyzed
for actinide isotopes. The remaining portion is retained at the NHRTR in frozen or formalin-fixed state for
future studies. Currently, the NHRTR holds ~9,000 frozen and formalin-fixed tissue samples from 40
whole- and 92 partial-body USTUR donors, and ~10,000 acid-digested tissue samples (acid solutions). The
NHRTR also houses frozen, ashed, dried, and plastic-embedded bone samples from the radium studies
carried out by Argonne National Laboratory/Argonne Cancer Research Hospital, the Massachusetts
Institute of Technology, and the New Jersey Radium Research Project. The NHRTR tissue materials: frozen,
formalin-fixed, paraffin-embedded, or acid-digested tissues are available to qualified scientists for their
research upon request. To qualify for receipt of USTU/NHRTR samples, researchers must (i) provide a brief
summary of the intended use of the samples, (ii) sign a confidentiality statement agreeing to protect the
identities of subjects; (iii) provide a copy of Institutional Review Board for Protection of Human Subject
approval, if appropriate. The USTUR authorship of published papers is not a condition for collaboration;
however, acknowledgement of the source of the materials is required. Recently, the USTUR/NHRTR
archived tissue materials were used by national and international researchers to study (i) elemental bio
imaging of actinides and beryllium; (ii) microdistribution and long-term retention of plutonium-nitrate in
the respiratory tract and its carcinogenic and inflammatory effects; (iii) distribution of actinides using
synchrotron radiation micro X-ray fluorescence spectrometry; (iv) beryllium distribution in the human
body.
49 | P a g e
1
1
(S902) Continuous exploration of JANUS archives. Tatjana Paunesku ; Benjamin M. Haley ; William Liu ;
2
1
1
1
Sumita Raha ; Beau M. Wanzer ; Lydia Finney ; and Gayle E. Woloschak, Northwestern University,
2
Chicago, IL and Advanced Photon Source, Argonne, IL
1
During the cold war era thousands of animals in US were exposed to radiation at different doses
and dose rates of radiation matching radiation qualities expected from a nuclear catastrophe. While
contemporary interests in radiation have shifted to types of exposures expected from therapeutic
radiation or space radiation, almost no new animal experiments are conducted where irradiated model
organisms are allowed to live out their natural lifespan after irradiation treatment. Radiobiological
archives still provide the only source of lifetime data on hundreds and thousands of irradiated mice, rats
and dogs. Our laboratory has collected both data and animal materials from these historic irradiation
experiments and continues to explore both with new computational and biotechnological tools.
(S903) The National Human Radiobiological Tissue Repository: a unique resource for scientists.
Sergei Tolmachev, Washington State University, Pullman, WA
The United States Transuranium and Uranium Registries (USTUR), and the associated National
Human Radiobiology Tissue Repository (NHRTR), is a federal-grant program funded by U.S. Department
of Energy and operated by College of Pharmacy at Washington State University in Richland, WA. The
USTUR studies the biokinetics and internal dosimetry of actinides (uranium, thorium, plutonium, and
americium) in occupationally exposed individuals who volunteer their bodies (partially or entirely) for
scientific use posthumously. A portion of the tissues received by the USTUR is radiochemically analyzed
for actinide isotopes. The remaining portion is retained at the NHRTR in frozen or formalin-fixed state for
future studies. Currently, the NHRTR holds ~9,000 frozen and formalin-fixed tissue samples from 40
whole- and 92 partial-body USTUR donors, and ~10,000 acid-digested tissue samples (acid solutions). The
NHRTR also houses frozen, ashed, dried, and plastic-embedded bone samples from the radium studies
carried out by Argonne National Laboratory/Argonne Cancer Research Hospital, the Massachusetts
Institute of Technology, and the New Jersey Radium Research Project. The NHRTR tissue materials: frozen,
formalin-fixed, paraffin-embedded, or acid-digested tissues are available to qualified scientists for their
research upon request. To qualify for receipt of USTU/NHRTR samples, researchers must (i) provide a brief
summary of the intended use of the samples, (ii) sign a confidentiality statement agreeing to protect the
identities of subjects; (iii) provide a copy of Institutional Review Board for Protection of Human Subject
approval, if appropriate. The USTUR authorship of published papers is not a condition for collaboration;
however, acknowledgement of the source of the materials is required. Recently, the USTUR/NHRTR
archived tissue materials were used by national and international researchers to study (i) elemental bio
imaging of actinides and beryllium; (ii) microdistribution and long-term retention of plutonium-nitrate in
the respiratory tract and its carcinogenic and inflammatory effects; (iii) distribution of actinides using
synchrotron radiation micro X-ray fluorescence spectrometry; (iv) beryllium distribution in the human
body.
49 | P a g e
