Page 36 - P4304.1-V91_PS-Magazine-November 2023 PRINT

Acepiro
Acepiro Prescribe Acepiro
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600 mg Effervescent Tablets
The new Drug Tariff tab tool 600 mg Effervescent Tablets by brand

Acetylcysteine
The Drug Tariff tab is found on the PSUK Portal alongside the other ordering Acetylcysteine
tools available to you. When you click on the tab it will list all the lines you
have ordered in the current month, which are over DT price.

Acepiro is indicated in adults as a mucolytic agent
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IMPORTANT. for the treatment of respiratory tract diseases in SIMPLE
These supplies are not yet above concession price – they which a reduction in bronchial secretion viscosity is
required to facilitate expectoration.
1
are just above tariff price, so please PLEASE do not start EFFECTIVE
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altering/endorsing all these prescriptions. You need to wait Prescribing Acepiro by brand is the least
until concessionary prices are finalised and this won’t be expensive way of prescribing a mucolytic even
compared to prescribing by generic name .
2,3
until the last few days in the month. ECONOMICAL
Prescribing Acepiro (Acetylcysteine
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600 mg effervescent tablets) by brand would save
£18.26m to the NHS when compared to generic
Carbocisteine, Mucodyne , generic Acetylcysteine
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and Nacsys . (PACT data to February 2023).
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Manufacturer Discount Scheme available to 30%
dispensing practices offering a discount of

Product PIP NHS MDS Net Rebate
Code Price
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Acepiro 600mg 4197638 £3.65 30% £2.56 £1.09
effervescent tablets x20

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*Compared to generic and branded carbocisteine and generic and branded acetylcysteine (Nacsys ).
Acepiro 600 mg effervescent tablets – Abbreviated have been reported by at least one in a thousand and less than one in a hundred
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Prescribing Information patients treated with acetylcysteine – hypersensitivity reactions, headache, tinnitus,
tachycardia, stomatitis, abdominal pain, nausea, vomiting, diarrhoea, pruritus,
Please refer to the Summary of Product Characteristics (SmPC) before prescribing urticaria, exanthema, rash, angioedema, pyrexia and lowered blood pressure. The
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Acepiro 600mg effervescent tablets. incidence of facial oedema has not been established. Overdose There have been
no reports of toxic overdose with oral acetylcysteine. In the case of an overdose of
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Each tablet contains 600 mg acetylcysteine. Uses Acepiro is indicated in adults as a Acepiro , management should be supportive. Effects on the ability to drive and/or
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mucolytic agent for the treatment of respiratory tract diseases in which a reduction operate machines Acepiro has no effect on the ability to drive or operate machines.
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in bronchial secretion viscosity is required to facilitate expectoration. Dosage and
Administration One tablet daily after food. Each tablet should be dissolved in half a Legal category: POM
glass of water. Duration of therapy should be determined by the treating physician. Pack size: 20 or 30 effervescent tablets in strips of laminated aluminium paper foil.
When concession prices for the month are finalised, as per the narrative Special Warnings and Precautions Hypersensitivity to the active substance or Shelf life: 3 years.
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on the screen, the list will be cleansed and only any items remaining over to any of the excipients. Acepiro should not be used by adolescents or children. NHS price: 20 effervescent tablets = £3.65
Use with caution in patients with a history of asthma or bronchospasm. Should
30 effervescent tablets = £4.40
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tariff will be left for you to consider. Hopefully these lines will be few and far bronchospasm occur Acepiro should be discontinued immediately. Very rarely, Marketing Authorisation Holder: Stirling Anglian Pharmaceuticals Ltd, Hillington
serious skin reactions such as Stevens-Johnson syndrome and Lyell syndrome have
between, and any over concession price will be by a few pence and not worth been reported. Patients should be advised to seek immediate medical advice in the Park Innovation Centre, 1 Ainslie Road, Hillington Park, Glasgow G52 4RU
presence of new skin or mucosal lesions. Administer with caution in patients with
worrying about. a reduced cough reflex for example elderly or frail patients. Postural drainage and Marketing Authorisation Number: PL 42582/0015
broncho-aspiration should be performed in patients unable to cough up bronchial Further information is available at medinfo@stirlinganglianpharmaceuticals.com
Again, my opinion is that you have bigger fish to fry, when it comes to profits, secretions effectively. Incompletely dissolved tablets present a risk of choking and or via the office number 0141 585 6352
aspiration, particularly to elderly patients. Use with caution in patients with a history
Date of preparation: 23 December 2022
than concessions BUT this tool does illustrate how APM will address most of of peptic ulcer disease or histamine intolerance. Hepatic and renal impairment Unique Code: API-004-22-001 2.0
can reduce clearance and increase systemic acetylcysteine plasma levels which
the concession lines without you lifting a finger. Reassuring I think; I hope you may result in an increase in adverse drug reactions due to drug accumulation.
do too. Contraindications Hereditary problems of galactose intolerance, total lactase Adverse events should be reported. Reporting forms and information can 0040030021 v 1.0 | Date of preparation: May 2023
deficiency or glucose-galactose malabsorption. Interactions with other medicinal
products In vitro tests indicate that (tetracycline, aminoglycosides and penicillin be found at http://yellowcard.mhra.gov.uk or downloaded from Google Play
(Please note, the Drug Tariff tab only works if you place your orders via the are inactivated when mixed directly with acetylcysteine. Where concomitant use or the Apple App store. Adverse events should also be reported to JensonR+
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of Acepiro and oral antibiotics is required, separate administration by an interval
PSUK Portal not via your clinical system. Confused me to start with!) of at least two hours. Acetylcysteine may potentiate the vasodilatory effect of on 01271 314 320 or Stirling Anglian Pharmaceuticals on 0141 585 6352.
nitroglycerine. Do not administer concurrently with ACE inhibitors or antitussives.
Acetylcysteine may reduce the bioavailability of certain heavy metal salts and should
be taken separately at different times of the day. Pregnancy fertility and Lactation
Administration of acetylcysteine during pregnancy and lactation should take
Get in touch with me at place only after a strict risk benefit assessment. Side Effects The following events
carolinepond@chasepeople.com
References:
36 PS Magazine | The PSUK Portal and the New Drug Tariff (DT) tab Buy direct online at PSUK.co.uk 1. Acepiro Summary of Product Characteristics. Available at https://www.medicines.org.uk/emc/product/13849/. Date accessed May 2023
2. British National Formulary available at https://bnf.nice.org.uk/drugs/acetylcysteine. Date accessed May 2023
3. NHS England and Wales Drug Tariff March 2023 available at https://www.drugtariff.nhsbsa.nhs.uk/#/00834576-DD_1/DD00834564/Home. Date accessed May 2023
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