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2 mg/5 ml
              Boosting your margin with Numark own brand                                                                                                                                                                       (400 mcg/ml)


              We’re proud to offer the largest own brand range available in wholesale, with 350 high-                                                                                                                                strength
              quality, low-priced products tailored for pharmacies and exclusive to Numark members. By                              The first non-branded 2 mg/5 ml
              choosing to retail Numark branded products alongside leading brands, you can boost your
              margin by up to £800 a month!                                                                                         glycopyrronium bromide oral solution

              Huge savings with Discount Partners
                                                                                                                                    An opportunity for adolescents to continue their treatment into adulthood
              Our Numark Discount Partners proposition connects you with a variety of carefully
              reviewed and vetted suppliers, offering discounts on products and services to support your                            For the symptomatic treatment of severe sialorrhoea (chronic
              daily business needs.                                                                                                 pathological drooling) due to chronic neurological disorders of
                                                                                                                                    childhood-onset in patients aged 3 years and older.
                                                                                                                                                                                          1
              Whether you need packaging, trays, bottles, or cartons for your dispensary, pharmacy
              refrigeration, office equipment, shop floor retail products, staff training support, or help
              setting up services in your pharmacy, our Discount Partners suppliers are here to help.                                Colonis Glycopyrronium Bromide 2 mg/5 ml Oral Solution
                                                                                                                                     gives patients the opportunity to continue their stable dose
              By the end of 2024, we welcomed 12 new Numark Discount Partner suppliers and                                           into adulthood.  1
              introduced two additional insurance products under Numark Insurance. Members can
              save up to £597 a month with the top 10 suppliers and collectively saved £1.4 million last                            •  The 2 mg/5 ml solution is available in 60 ml and 250 ml bottles.
              year, thanks to our extensive network of suppliers. See what’s available to you on your
              Dashboard!                                                                                                            •  Sugar-free, strawberry flavour – strawberry is the most popular
                                                                                                                                     flavour with children. 2
              Generating additional revenue by delivering private services                                                          •  A formulation suited for children with swallowing issues. 3


              Private services can offer you a way to diversify your revenue streams beyond traditional                             •  Licensed for use with nasogastric and/or PEG tubes. 1
              NHS prescriptions, bringing several key benefits.                                                                                                                                         PIP Codes: 128-0841 (60 ml), 128-0833 (250 ml)


              Paid services can significantly boost your income and increase footfall by attracting                                             Colonis Glycopyrronium Bromide Oral Solution 2 mg/5 ml is now
              more patients, who may also purchase additional items during their visits. Additionally,                                                            available to order via Phoenix
              private services enhance patient loyalty by meeting a broader range of healthcare needs,
              fostering lasting relationships, and encouraging repeat visits and word-of-mouth referrals.
              Through our support, resources, and discounted equipment, you can offer various private                               PRESCRIBING INFORMATION                                 inhaled anaesthetics. May delay absorption of other medication. Concurrent use with slow-
                                                                                                                                                                                            dissolving tablets of digoxin, atenolol or metformin may result in increased serum levels of these
                                                                                                                                    Please consult the Summary of Product Characteristics (SmPC) before prescribing.
              services:                                                                                                             Product name: Glycopyrronium Bromide 2 mg/5 ml Oral Solution  medicines. Use with parasympathomimetics may antagonise the effect.
                                                                                                                                                                                            Adverse effects:
                                                                                                                                    Composition: Each 5 ml contains 2 mg of glycopyrronium bromide   Serious: Allergic reaction, seizure (worsening), transient bradycardia, angle-closure glaucoma,
                                                                                                                                    Indications: Symptomatic treatment of severe sialorrhoea (chronic pathological drooling) due to   urinary retention (common), pneumonia (common), pyrexia (common), behavioural
              •  Vaccinations and immunisations, like flu, travel, private COVID-19, and HPV vaccines,                              chronic neurological disorders of childhood-onset in patients aged 3 years and older.  changes (very common)
                  can also enhance income. You could potentially earn £350 a month from five private                                Dosage and administration: Dosing is based on the weight of the child. Using the graduated   Very common: Dry mouth, constipation, diarrhoea, vomiting, flushing, nasal congestion, reduced
                                                                                                                                                                                            bronchial secretions. Consult the SmPC for further details and for other adverse reactions.
                                                                                                                                    syringe provided, initiate dosing at 0.02 mg/kg three times daily and titrate in increments of
                  pneumococcal vaccinations.                                                                                        0.02 mg/kg every 5-7 days. Adjust dose to achieve optimal symptomatic control with minimal   NHS price: 60 ml: £76.80, 250 ml: £320
                                                                                                                                    adverse effects. The maximum recommended dosage is 0.1 mg/kg three times daily not
                                                                                                                                    exceeding 1.5-3 mg per dose based on weight. Refer to dosing table (Table 1) in Summary of   Legal category: Prescription Only Medicine
              •  Travel health services, including consultations, vaccinations, anti-malarial treatments,                           Product Characteristics. Dose should be given one hour before or two hours after meals. For oral   Marketing Authorisation Holder: Colonis Pharma Limited, 25 Bedford Square, Bloomsbury,
                                                                                                                                                                                            London, WC1B 3HH, United Kingdom
                                                                                                                                    use and use via nasogastric & PEG feeding tubes.
                  and health kits, can bring in an average of £380 profit per popular destination per                               Contraindications: Hypersensitivity to glycopyrronium bromide or excipients; angle-closure   MA number: PL 41344/0071
                  patient.                                                                                                          glaucoma; myasthenia gravis; pyloric stenosis; paralytic ileus; prostatic enlargement; urinary   Job number: GB-CPL-066-001
                                                                                                                                    retention; severe renal impairment (eGFR < 30 ml/min/1.73 m , including those with end-stage
                                                                                                                                                                     2
                                                                                                                                    renal disease requiring dialysis); intestinal obstruction; pregnancy & breastfeeding; potassium   Date of preparation: December 2024
              •  Specialised clinics for weight management, smoking cessation, sexual health, allergy                               chloride solid oral dose products; other anticholinergic drugs. Contraindicated during pregnancy
                                                                                                                                    and whilst breastfeeding.
                  management, and aesthetic treatments can further increase profitability, with private                             Warnings and precautions: Not recommended in children under 3 years and should not be used   Adverse events should be reported. Reporting forms and information can be found
                                                                                                                                                                                             at: https://yellowcard.mhra.gov.uk/ or search for MHRA Yellow Card in the Google Play or
                  weight management services alone offering earnings between £984 and £1,524 per                                    in children with mild to moderate sialorrhoea or in patients over 65 years. Use with caution in   Apple App Store. Adverse events should also be reported to Colonis Pharma Limited via
                                                                                                                                    children with compromised blood brain barrier. Reduced dose should be considered for patients
                                                                                                                                                                                             Clinigen E-mail: drugsafety@clinigengroup.com
                                                                                                                                    with renal failure. Use with caution in gastro-oesophageal reflux disease, ulcerative colitis,
                  patient.                                                                                                          pre-existing constipation, acute myocardial infarction, hypertension, conditions characterised   Fax number: +44 (0) 1932 824284
                                                                                                                                    by tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), coronary
                                                                                                                                    artery disease, cardiac arrhythmias, patients receiving inhalation anaesthesia. Diarrhoea may   Abbreviation
                                                                                                                                    be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy   PEG, percutaneous endoscopic gastronomy.
              By embracing the diverse opportunities available and fully utilising the benefits of your                             or colostomy, and treatment with this drug would be inappropriate and possibly harmful. As   References
                                                                                                                                    glycopyrronium bromide inhibits sweating, patients with increased temperature should be
              Numark membership, your pharmacy can thrive amidst financial challenges. These                                        observed closely. In high environmental temperature, heat prostration can occur. Avoid repeated   1.  Colonis Pharma Ltd. Glycopyrronium Bromide 2 mg/5 ml Oral Solution Summary of Product
                                                                                                                                                                                             Characteristics. Available from: https://www.medicines.org.uk/emc/.
                                                                                                                                    or large doses in patients with uraemia. Patients with fructose intolerance should not take this
              strategies help you manage the rising costs of National Insurance and the National Living                             medicine due to presence of sorbitol. The product contains sodium propyl parahydroxybenzoate   2.  Generation R. What flavour would children choose for their medicines? Available from: https://
                                                                                                                                                                                             generationr.org.uk/what-flavour-would-children-choose-for-their-medicines/
                                                                                                                                    (E217) and sodium methyl parahydroxybenzoate (E219) which may cause allergic reactions
                                                                                                                                                                                             [Accessed January 2025].
              Wage, while also ensuring long-term sustainability and growth. Together, we can foster a                              (possibly delayed). Treatment should be evaluated in the event of constipation, overheating,   3.  Batchelor HK and Mariott JF. Formulations for children; problems and solutions. Br J Pharmacol.
                                                                                                                                    urinary retention, pneumonia, allergic reaction, pyrexia, very hot weather, changes in behaviour.
              community that’s not only resilient but also flourishing. Let’s continue to work hand-in-                             Safety data beyond 24 weeks are not available. Treatment should be kept as short as possible.   2015;79(3):405–418.
                                                                                                                                    May produce drowsiness or blurred vision, thus patients should not operate machinery.
              hand towards creating thriving community pharmacies that meet the evolving needs of                                   Drug interactions: Combinations with drugs with antimuscarinic effects (e.g. amantadine,   © Colonis Pharma Limited 2025
                                                                                                                                                                                            Registered in England & Wales No. 05486832. For more information please view our Privacy
              our patients, enhancing both care and profitability.                                                                  tricyclic antidepressants, antihistamines, clozapine; disopyramide; MAOIs, nefopam; memantine,   Policy. VAT Registration No. 862418028. Registered office: Colonis Pharma Ltd, 25 Bedford Square,
                                                                                                                                    phenothiazines) may add to adverse effects and can also lead to confusion in the elderly. Use
                                                                                                                                    with corticosteroids may result in increased intraocular pressure. There are specific interactions   Bloomsbury, London, WC1B 3HH.
                                                                                                                                    with domperidone, metoclopramide, levodopa, haloperidol; nitrates; topiramate, zonisamide;   January 2025 | GB-CPL-066-002
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