Page 27 - P4304.1-V94_PS-Magazine-February 2024 PRINT

Helping your patients live Tips from your

in harmony with creatures

great and small Live like you Dispensing Doctor

Ryaltris is indicated in adults and
adolescents 12 years of age and older
for the treatment of moderate to Account Manager
severe nasal symptoms associated
with allergic rhinitis (AR). 1
Julie Darley,

DDAM for East of England

Julie Darley is one of PSUK most experienced account
managers, working with dispensing practices for over 37
years and supporting PSUK members for over 10 years
saving money and improving dispensary profits. This
month Julie shares some of her insights and top tips
that are often discussed with her customers.

With over 100 years of total experience, working solely with
dispensing practices, the PSUK account manager team are far
more than just average account managers. We have first-hand
Ryaltris combination intranasal spray can bring symptom market insight, commercial knowledge and provide extensive
®
relief within 10-15 minutes* from allergic rhinitis triggered by information enabling you to make well informed balanced
decisions, supporting your drive for efficiency savings, compliance
perennial factors such as animal dander and dust mites. 1-4 improvement and increased margin. Our approach to account
*Findings from one environmental exposure chamber study and two large randomised controlled trials. 2-4 management fully supports our PSUK mantra of ‘Conquering
Ryaltris is generally well tolerated; the most commonly-reported adverse reactions are dysgeusia, tomorrow together’.
epistaxis and nasal discomfort. 1,2,5
Scan to visit
Find out more at www.ryaltris.co.uk www.ryaltris.co.uk Your practice will no doubt have recently reviewed your 22/23
annual accounts which hopefully, will have shown to be healthy!
However, considering the current economic climate that everyone

Ryaltris Prescribing Information during periods of stress or elective surgery. The replacement of a systemic corticosteroid will be facing in their personal lives, you may have seen a slight
Ryaltris (mometasone furoate and olopatadine hydrochloride) Please refer to the with a topical corticosteroid can be accompanied by signs of adrenal insufficiency, and
Summary of Product Characteristics (SmPC) before prescribing. One delivered dose some patients may experience symptoms of withdrawal. Patients previously treated for decline in practice profit. This is where PSUK account managers
contains mometasone furoate monohydrate equivalent to 25 microgram mometasone prolonged periods with systemic corticosteroids and transferred to topical corticosteroids
furoate and olopatadine hydrochloride equivalent to 600 micrograms olopatadine. should be carefully monitored for acute adrenal insufficiency in response to stress. come into their own and demonstrate that we are more than
Indication: treatment of moderate to severe nasal symptoms associated with allergic In those patients who have asthma or other clinical conditions requiring long term
rhinitis in adults and adolescents 12 years of age and older Posology and method of systemic corticosteroid treatment, too rapid a decrease in systemic corticosteroids may just a wholesaler moving boxes.
administration: The usual recommended dose is two actuations in each nostril twice cause a severe exacerbation of their symptoms. Somnolence: in isolated cases dizziness,
daily (morning and evening). Children below 12 years: Ryaltris is not recommended. lethargy, fatigue and somnolence may occur when using Ryaltris. In these cases, the
Elderly: No dose adjustment required. Renal and hepatic impairment: there are no data ability to drive and use machines may be impaired. Alcohol and other CNS depressants
in patients with renal and hepatic impairment, however no dose adjustment is expected may enhance this effect. Antihistamine effects: concomitant use of other antihistaminic
to be required. Contraindications: Hypersensitivity to the active substances or to any of drugs administered may increase the risk of antihistamine adverse effects. Paediatric
the excipients. Ryaltris should not be used in the presence of untreated localised infection population: It is recommended that the height of children receiving prolonged treatment
involving the nasal mucosa, such as herpes simplex. Patients who have experienced recent with nasal corticosteroids is regularly monitored. If growth is slowed, therapy should be
nasal surgery or trauma should not use a nasal corticosteroid until healing has occurred. reviewed with the aim of reducing the dose of nasal corticosteroid if possible, to the lowest
Precautions: Local nasal effects: nasal ulceration and nasal septal perforation have been dose at which effective control of symptoms is maintained. Excipients: Ryaltris contains How can PSUK assist you to
reported in patients following intranasal antihistamines. Nasal septal perforation has been 0.02 mg benzalkonium chloride in each actuation. Benzalkonium chloride may cause
reported following intranasal corticosteroids. Patients using Ryaltris over several months irritation or swelling inside the nose, especially if used for a long time. Adverse reactions:
or longer should be examined periodically for possible changes in the nasal mucosa. Common (≥1/100 to <1/10): dysgeusia (unpleasant taste), epistaxis, nasal discomfort. reduce any losses?
Ryaltris is not recommended in cases of nasal septum perforation. In clinical studies with Uncommon (≥1/1,000 to <1/100): dizziness, headaches, somnolence, nasal dryness, dry
mometasone furoate administered intranasally, the development of localised infections mouth, abdominal pain, nausea, fatigue. Rare (≥1/10,000 to <1/1000) bacterial vaginosis,
of the nose and pharynx with Candida albicans has occurred; may require treatment and anxiety, depression, insomnia, lethargy, migraine, blurred vision, dry eye, eye discomfort, The first thing to note is that the NHS contract is
discontinuation of Ryaltris. Patients using Ryaltris over several months or longer should be ear pain, nasal inflammation, nasal mucosal disorder, oropharyngeal pain, sneezing,
examined periodically for evidence of Candida infection or other signs of adverse effects throat irritation, constipation, sore tongue, laceration. Incidence not known (reported fundamentally set up to allow practices to make a
on the nasal mucosa. Visual disturbances may be reported with systemic and topical from use of corticosteroids): pharyngitis, upper respiratory tract infection, hypersensitivity
corticosteroid use. Symptoms such as blurred vision or other visual disturbances should including anaphylactic reactions, angioedema, bronchospasm, and dyspnoea, cataracts, profit on their generic purchases, with PSUK you will
be considered for ophthalmologist referral for evaluation of possible causes including glaucoma, increased intraocular pressure, nasal septum perforation. Marketing
cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR). authorisation number: PL 25258/0331 Marketing Authorisation Holder and distributer: always make money on your generic basket due to
Hypersensitivity Reactions including instances of wheezing, may occur. Discontinue Glenmark Pharmaceuticals Europe Limited, Laxmi House, 2B Draycott Avenue
Ryaltris if such reactions occur. Immunosuppression: Chickenpox and measles, for Kenton, Middlesex, HA3 0BU. United Kingdom Legal classification: POM Cost: £13.32. our market leading APM proposition. Where losses
example, can have a more serious or even fatal course in susceptible patients and those 1 bottle with 29 g suspension (240 actuations) Date of preparation: June 2021. Job
using corticosteroids. In children or adults who have not had these diseases or been number: PP-UK-RYAL-0001 tend to occur is predominantly on the branded side
properly immunized, particular care should be taken to avoid exposure. Corticosteroids
should be used with caution, if at all, in patients with active or quiescent tuberculous Adverse events should be reported. Reporting forms and information of your purchasing due to clawback, it is crucial that
infections of the respiratory tract, untreated local or systemic fungal or bacterial infections, can be found at https://yellowcard.mhra.gov.uk. Adverse events should
systemic viral or parasitic infections, or ocular herpes simplex because of the potential also be reported to Glenmark Pharmaceuticals Europe Ltd you minimise those losses through discounts/rebates
for worsening of these infections. Systemic Effects of Corticosteroids: potential systemic
effects may include Cushing’s syndrome, Cushingoid features, adrenal suppression, medical_information@glenmarkpharma.com or call 0800 458 0383 and potentially prescribing changes which we can
growth retardation in children and adolescents, cataract, glaucoma and more rarely, a
range of psychological or behavioural effects including psychomotor hyperactivity, sleep References: 1. Ryaltris Summary of Product Characteristics. 2. Gross GN, et al. Ann advise on through or loss-making line reports.
disorders, anxiety, depression or aggression (particularly in children). When intranasal Allergy Asthma Immunol 2019;122:630–638. 3. Hampel FC, et al. Allergy Asthma Proc
steroids are used at higher than recommended dosages or in susceptible individuals 2019;40(4):261–272. 4. Patel P, et al. Ann Allergy Asthma Immunol 2019;122(2):160–166.
at recommended dosages, systemic corticosteroid effects such as hypercorticism and 5. Segall N, et al. Allergy Asthma Proc 2019;40:301-310.
adrenal suppression may appear. If such changes occur, the dosage of Ryaltris should
be discontinued slowly, consistent with accepted procedures for discontinuing oral Ryaltris is a registered trademark of Glenmark Speciality S.A.
®
corticosteroid therapy. The concomitant use of intranasal corticosteroids with other
inhaled corticosteroids could increase the risk of signs or symptoms of hypercorticism © 2023 Glenmark Pharmaceuticals Europe Ltd.
and/or suppression of the HPA axis. If there is evidence for higher than recommended All rights reserved.
doses being used, then additional systemic corticosteroid cover should be considered Date of preparation: October 2023 PP-UK-RYAL-0338 V1
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or call us on 01904 558 350 Top tips from your DDAM | PS Magazine 27
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