Page 10 - Pharmaceutical_Analytical_Chemistry_1_Theoretical_Notes_Level_1
P. 10

Mansoura National University
            Pharm D-Clinical Pharmacy Program                 Level 1             Pharm. Anal. Chem. 1 (PC 101)


                                                     B) Electrolytes


                          Strong electrolytes                             Weak electrolytes

                ✓  Substances  that  are  completely  ✓  Substances that dissociate to a small

                    dissociated in an aqueous solution.         extent in an aqueous solution.

                ✓  Their      solution    can     conduct  ✓  They are weakly conductive to electric

                    electricity.                                current.

                ✓  e.g. NaCl and HCl                        ✓   e.g. acetic acid, water


                 Examples: Strong acid, strong                                            -7
                                                             a) H O ionizes to only 10  M:
                 bases, salts of strong acid and                  2                          +          -
                                                             H O     + H O                 H O    + OH
                 base.                                         2  (aq)   2                3   (aq)       (aq)

                                        -
                                                     +
                 HCl (aq)  +  H 2O  → Cl (aq)  +  H 3O (aq)   b) CH COOH ionizes to only 0.42%
                                                                    3
                                                             w/v:
                                                                                                        -
                                                               CH COOH         + H O           CH COO
                                                                   3       (aq)    2              3      (aq)
                                                                                                        +
                                                                                                 +H O
                                                                                                     3   (aq)
                                                             c) NH OH and HCN.
                                                                    4



                                                      Solubility

            Solubility  is  a  measure  of  how  a  solute  will  dissolve  in  a  solvent  at  a  constant

            temperature.

                   ❖ Soluble: can dissolve in a solvent.

                   ❖ Insoluble: can not dissolve in a solvent.

            Ionic compounds are soluble in polar solvents & have

            low solubility in nonpolar solvents. E.g.: NaCl dissolves in water.






                                                              5
   5   6   7   8   9   10   11   12   13   14   15