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Effects of cholesterol in treatment of Hypertension

-abnormalities of lipoprotein metabolism occur more frequently in patients with hypertension and
hypercholesterolemia impairs endothelium-dependent relaxation long before the formation of atherosclerosis.(3)

-The majority of cholesterol studies have focused on isolated peripheral vessels and there is a lack of
information as to whether cholesterol effects systemic hemodynamics.

-findings suggest that hypercholesterolemia is related to hyperreactivity to stress and this greater BP response to
mental stress may contribute to the increased prevalence of hypertension in this population.

-The present study also suggests that cholesterol levels are associated with BP; thus, lowering cholesterol may
have a role in the overall control of BP.(4)

References

• (1)Larsen MK, Matchkov VV. Hypertension and physical exercise: The role of oxidative stress. Medicina. 2016
Feb;52(1):19-27.

• (2) Siegel WC, Blumenthal JA. The role of exercise in the prevention and treatment of hypertension. Annals of Behavioral
Medicine. 1991 Mar 1;13(1):23-30.

• (3)Creager MA, Gallagher SJ, Girerd XJet al. : L-Arginine improves endothelium-dependent vasodilation in
hypercholesterolemic humans. J Clin Invest 1992;90:1248–1253

• (4) Cohen RA, Zitnay KM, Haudenschild CCet al. : Loss of selective endothelial cell vasoactive functions caused by
hypercholesterolemia in pig coronary arteries. Circ Res 1988;63:903–910

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