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CLINICAL PRACTICE GUIDELINES              MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)



               Group  3:  Depression  and  Depression same as for group 2; genetic risk defined as first-

             genetic risk  Depression  and  Depression same as for group 2; genetic risk defined as first-
              Group  3:          degree relative with BD
                  genetic risk   degree relative with BD
               Group  3:  Depression  and  Depression same as for group 2; genetic risk defined as first-
             Adapted: Bechdolf A, Nelson B, Cotton SM, et al. A preliminary evaluation of the validity of at-risk

                                degree relative with BD
             genetic risk
                      Group  3:  Depression  and  Depression same as for group 2; genetic risk defined as first-
                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.

              Adapted: Bechdolf A, Nelson B, Cotton SM, et al. A preliminary evaluation of the validity of at-risk
              Group       3:  Depression  and  Depression same as for group 2; genetic risk defined as first-
                   2010;127(1-3):316-20  degree relative with BD
             genetic risk
            Adapted: Bechdolf A, Nelson B, Cotton SM, et al. A preliminary evaluation of the validity of at-risk
                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.
             Group  3:  Depression  and  Depression same as for group 2; genetic risk defined as first-
              genetic risk      degree relative with BD
              Group  3:  Depression  and  Depression same as for group 2; genetic risk defined as first-
                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.
                     sk
              genetic ri 2010;127(1-3):316-20  degree relative with BD
             Group  3:  Depression  and
                   2010;127(1-3):316-20  Depression same as for group 2; genetic risk defined as first-
            Adapted: Bechdolf A, Nelson B, Cotton SM, et al. A preliminary evaluation of the validity of at-risk
             A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years
                                degree relative with BD

              genetic risk
            Adapted: Bechdolf A, Nelson B, Cotton SM, et al. A preliminary evaluation of the validity of at-risk

                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.
                                degree
              genetic risk      20, level II-2relative with BD
                                       SM, et al. A preliminary evaluation of the validity of at-risk
             of follow-up and showed that:
            Adapted: Bechdolf A, Nelson B, Cotton

            A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years

                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.
                   2010;127(1-3):316-20

              Adapted: Bechdolf A, Nelson B, Cotton SM, et al. A preliminary evaluation of the validity of at-risk
                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.
            A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years

                28.6% of subjects from BAR group developed BD over a mean of 11.1 years whilst none
            of follow-up and showed that:
                     2010;127(1-3):316-20  20, level II-2
            Adapted: Bechdolf A, Nelson B, Cotton SM, et al. A preliminary evaluation of the validity of at-risk

                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.
                   2010;127(1-3):316-20

            of follow-up and showed that:

                                20, level II-2
                developed BD in a clinically matched comparison group. Of these: .1 years whilst none
                28.6% of subjects from BAR group developed BD over a mean of 11
                   criteria for bipolar disorders in help-seeking adolescents and young adults. J Affect Disord.
            A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years
                   2010;127(1-3):316-20

                28.6% of subjects from BAR group developed BD over a mean of 11.1 years whilst none
            A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years
                o  87.5% transitions were to BD II and 12.5% to BD I p. Of these:
                developed BD in a clinically matched comparison grou

            of follow-up and showed that:

                   2010;127(1-3):316-20  20, level II-2
            A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years
                developed BD in a clinically matched comparison group. Of these:

              of follow-up and showed that:
                o  87.5% transitions were to BD II and 12.5% to BD I
                                20, level II-2
                o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with
                28.6% of subjects from BAR group developed BD over a mean of 11.1 years whilst none
            A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years
            of follow-up and showed that:

                                20, level II-2
                o  87.5% transitions were to BD II and 12.5% to BD I
                  major depression and cyclothymic features D over a mean of 11.1 years whilst none
                28.6% of subjects from BAR group developed B
            A cohort study assessed the association of BAR criteria and onset of BD over 10 to 13 years
                o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with

            of follow-up and showed that:
                developed BD in a clinically matched comparison group. Of these:
                                20, level II-2
                28.6% of subjects from BAR group developed BD over a mean of 11.1 years whilst none
                 o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with

                  major depression an
            of follow-up and showed that:d cyclothymic features
                developed BD in a clinically matched comparison group. Of these:
                                20, level II-2
                28.6% of subjects from BAR group developed BD over a mean of 11.1 years whilst none
                o  87.5% transitions were to BD II and 12.5% to BD I
                developed BD in a clinically matched comparison group. Of these:
                  major depression and cyclothymic features
                o  87.5% transitions were to BD II and 12.5% to BD I
                28.6% of subjects from BAR group developed BD over a mean of 11.1 years whilst none

                developed BD in a clinically matched comparison group. Of these:
                o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with
                o  87.5% transitions were to BD II and 12.5% to BD I
               Patients with suspected unipolar depression should be screened for BD.
                o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with
                 developed BD in a clinically matched comparison group. Of these:
                  major depression and cyclothymic features
                o  87.5% transitions were to BD II and 12.5% to BD I
               There is inadequate evidence to recommend a specific screening tool for BD in primary
                o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with
               Patients with suspected unipolar depression should be screened for BD.
                  major depression and cyclothymic features
                o  87.5% transitions were to BD II and 12.5% to BD I
                 o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with
               Patients with suspected unipolar depression should be screened for BD.
               care.  major depression and cyclothymic features
               There is inadequate evidence to recommend a specific screening tool for BD in primary

                o  75.0% transitions occurred in those with subthreshold mania and 25.0% in those with
                  major depression and cyclothymic features
               There is inadequate evidence to recommend a specific screening tool for BD in primary
                care.
               Clinical diagnostic assessment should follow any positive screening for BD.
               Patients with suspected unipolar depression should be screened for BD.
                  major depression and cyclothymic features

               care.
               Patients with suspected unipolar depression should be screened for BD.
               Clinical diagnostic assessment should follow any positive screening for BD.
                  There is inadequate evidence to recommend a specific screening tool for BD in primary
                 Patients with suspected unipolar depression should be screened for BD.
               Clinical diagnostic assessment should follow any positive screening for BD.
               There is inadequate evidence to recommend a specific screening tool for BD in primary
               care.
               Patients with suspected unipolar depression should be screened for BD.
             3.2.  Differential Diagnoses

               There is inadequate evidence to recommend a specific screening tool for BD in primary
               care.
               Patients with suspected unipolar depression should be screened for BD.
               There is inadequate evidence to recommend a specific screening tool for BD in primary
                Clinical diagnostic assessment should follow any positive screening for BD.
                 care.
            3.2.  Differential Diagnoses
               Clinical diagnostic assessment should follow any positive screening for BD.
               There is inadequate evidence to recommend a specific screening tool for BD in primary
               care.
            3.2.  Differential Diagnoses
             Symptoms of BD can overlap with other disorders. A comprehensive current and longitudinal
             
                 Clinical diagnostic assessment should follow any positive screening for BD.

               care.
                Clinical diagnostic assessment should follow any positive screening for BD.

            Symptoms of BD can overlap with other disorders. A comprehensive current and longitudinal
             history, corroborative history from informants and relevant investigations are useful to rule out
            3.2.  Differential Diagnoses
               Clinical diagnostic assessment should follow any positive screening for BD.

            Symptoms of BD can overlap with other disorders. A comprehensive current and longitudinal
            3.2.  Differential Diagnoses
             the differential diagnoses in BD.
            history, corroborative history from informants and relevant investigations are useful to rule out


            3.2.  Differential Diagnoses
               history, corroborative history from informants and relevant investigations are useful to rule out

              the differential diagnoses in BD.
            Symptoms of BD can overlap with other disorders. A comprehensive current and longitudinal
            3.2.  Differential Diagnoses

            the differential diagnoses in BD.
            Symptoms of BD can overlap with other disorders. A comprehensive current and longitudinal
            3.2.  Differential Diagnoses
             Below are common differential diagnoses to be considered in BD:

            history, corroborative history from informants and relevant investigations are useful to rule out

            Symptoms of BD can overlap with other disorders. A comprehensive current and longitudinal
             a) during depressive episode -
                history, corroborative history from informants and relevant investigations are useful to rule out
            Below are common differential diagnoses to be considered in BD:
            Symptoms of BD can overlap wit
            the differential diagnoses in BD. h other disorders. A comprehensive current and longitudinal
            history, corroborative history from informants and relevant investigations are useful to rule out
            Below are common differential diagnoses to be considered in BD:
            the differential diagnoses in BD.
                                  6
            Symptoms of BD can overlap with other disorders. A comprehensive current and longitudinal
            a) during depressive episode -
                major depressive disorder
              history, corroborative history from informants and relevant investigations are useful to rule out
            the differential diagnoses in BD.

                major depressive disorder
                major depressive disorder with mixed episode
            history, corroborative history from informants and relevant investigations are useful to rule out
            a) during depressive episode -  6
                                               21, level III
            the differential diagnoses in BD.
            Below are common differential diagnoses to be considered in BD:

                major depressive disorder
            the differential diagnoses in BD.
            Below are common differential diagnoses to be considered in BD:
                major depressive disorder with mixed episode
                adjustment disorder with depressed mood
                                            6
            a) during depressive episode -

            Below are common differential diagnoses to be considered
                                              21, level III in BD:
                major depressive disorder with mixed episode
              a) during depressive epi
                adjustment disorde
                anxiety disorders  r with depressed mood
                                            6
            Below are common differential diagnoses to be considered in BD:
                major depressive disorder
            a) during depressive episode -
                major depressive disorder
                adjustment disorder with depressed mood
                                            6
            Below are common differential diagnoses to be considered in BD:
                anxiety disorders
                depressive disorder due to another medical condition
                           6
            a) during depressive episode -
                major depressive disorder with mixed episode
                                              21, level III
                major depressive disorder
                major depressive disorder with mixed epi
            a) during depressive epi 6sode -   6 6 6 6 6with mixed episode 21, level III         6 6     6
                                          6sode
                                              21, level III
                           6
                anxiety disorders  sode -  6
                                              21, level III
                depressive disorder due to another medical condition
                major depressive disorder
                adjustment disorder with depressed mood
                substance-induced depressive disorder   6
                major depressive disorder
                major depressive disorder  pressed mood
                                           6
                adjustment disorder with de
                depressive disorder due to another medical condition
                                            6
                substance-induced depressive disorder
                                          6
                major depressive disorder with mixed episode
                anxiety disorders
                           6
                adjustment disorder with depressed mood
                schizophrenia or schizoaffective disorder   6
                substance-induced depressive disorder  sode
                           6
                                              21, level III
                anxiety disorders
                schizophrenia or schizoaffective disorder
                adjustment disorder with depressed mood
             b) during mania or hypomania episode -    6  6  21, level III     6
                major depressive disorder with mixed epi 6
                depressive disorder due to another medical condition
                anxiety disorders
                           6
                adjustment disorder with depressed mood
                schizophrenia or schizoaffective disorder     condition
                depressive disorder due to another medical
                substance-induced bipolar disorder
            b) during mania or hypomania episode -   6  6  6 6  6 6
                           6
                anxiety disorders
                substance-induced depressive disorder
                depressive disorder due to another med
                anxiety disorders
                substance-induced depressive disorder
                           6
                                           6
            b) during mania or hypomania episode -   6  6ical condition    6
                substance-induced bipolar disorder
                bipolar and related disorder due to another medical condition
                depressive disorder due to another med
                                          6ical condition
                                                   6
                substance-induced depressive disorder
                schizophrenia or schizoaffective disorder
                depressive disorder due to another medical condition
                substance-induced bipolar disorder
                                           6
                schizophrenia or schizoaffective disorder
                schizophrenia or schizoaffective disorder
                bipolar and related disorder due to another medical condition
                substance-induced depressive disorder
                                           6
            b) during mania or hypomania episode -   6  6 6   6  6  6
                schizophrenia or schizoaffective disorder
                bipolar and related disorder duee -
            b) during mania or hypomania episod 6 to another medical condition
                                                        6
                schizophrenia or schizoaffective disorder
                substance-induced depressive disorder  6 6
                schizophrenia or schizoaffective disorder
                borderline personality disorder
                                       6
                substance-induced bipolar disorder
            b) during mania or hypomania episode -   6  6 6  22, level III
                 schizophrenia or schizoaffective disorder
                substance-induced bipolar disorder
                schizophrenia or schizoaffective disorder
                                    6
                borderline personality disorder
                 attention-deficit hyperactivity disorder (ADHD)
            b) during mania or hypomania episode -   6  6
                bipolar and related disorder due to another medical condition
                substance-induced bipolar disorder
            b) during mania or hypomania episod to another medical condition
                                                        6
                bipolar and related disorder due
                                    6
              
                                              22, level III
                 attention-deficit hyperactivity disorder (ADHD)
                substance-induced bipolar disorder
                 borderline personality disorder  e -   6
                schizophrenia or schizoaffective disorder
                                           6
                                                        6
                 bipolar and related disorder due to another medical condition
                                              22, level III
                                       6
                                           6
                 attention-deficit hyperactivity disorder (ADHD)
                schizophrenia or schizoaffective disorder
                substance-induced bipolar disorder
              In a narrative review comparing the overlap and differences of ADHD and BD, the authors
                bipolar and related disorder due to another medical condition
                                                        6
                borderline personality disorder
                                    6
                schizophrenia or schizoaffective disorder
                                           6
                bipolar and related disorder due to another medical condition
                 borderline personality disorder
              In a narrative review comparing the  6 22, level III    6  22, level III   6
             summarised the findings as follows:   overlap and differences of ADHD and BD, the authors
                schizophrenia or schizoaffective disorder
                 attention-deficit hyperactivity disorder (ADHD)
                                    6
                 borderline personality disorder
            In a narrative review comparing the overlap and differences of ADHD and BD, the authors
                                              22, level III
                                           6
                 attention-deficit hyperactivity disorder (ADHD)
                schizophrenia or schizoaffective disorder
                                    22, level III

            summarised the findings as follows:
              a) similarities  -  distractibility,  irritability,  insomnia,  poor  concentration,  talkativeness  and
                 borderline personality disorder
                                    6

                 attention-deficit hyperactivity disorder (ADHD)
                borderline personality disorder

            summarised the findings as follows: 6 22, level III    22, level III
               a) similarities  -  distractibil
                psychomotor agitation ity,  irritability,  insomnia,  poor  concentration,  talkativeness  and
            In a narrative review comparing the overlap and differences of ADHD and BD, the authors
                                              22, level III
                 attention-deficit hyperactivity disorder (ADHD)

               narrative review comparing the overlap and differences of ADHD and BD, the authors
              a) similarities  -  distractibility,  irritability,  insomnia,  poor  concentration,  talkativeness  and
                 attention-deficit hyperactivity disorder (ADHD)
            In a  psychomotor agitation
                                              22, level III
            summarised the findings as follows:


              b) differences were as follows - 22, level III
            In a narrative review comparing the overlap and differences of ADHD and BD, the authors
                psychomotor agitation

                                    22, level III
                 summarised the findings as follows:
              b) differences were as follows -
            In a narrative review comparing the overlap and differences of ADHD and BD, the authors
              a) similarities  -  distractibility,  irritability,  insomnia,  poor  concentration,  talkativeness  and
            summarised the findings as follows:
                                    22, level III

            In a narrative review comparing irritability,  insomnia,  poor  concentration,  talkativeness  and

              a) similarities  -  distractibility,
               b) differences were as follows -  the overlap and differences of ADHD and BD, the authors

                                    22, level III
                psychomotor agitation
              a) similarities  -  distractibility,  irritability,
                psychomotor agitation
                 summarised the findings as follows:
              summarised the findings as follows: 22, level III  insomnia,  poor  concentration,  talkativeness  and

              b) differences were as follows -  irritability,  insomnia,  poor  concentration,  talkativeness  and
              a) similarities  -  distractibility,
                psychomotor agitation
              a) similarities  -  distractibility,  irritability,  insomnia,  poor  concentration,  talkativeness  and
                     b) differences were as follows -
                psychomotor agitation
              b) differences were as follows -
                psychomotor agitation
                         b) differences were as follows -
                           b) differences were as follows -

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