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CLINICAL PRACTICE GUIDELINES              MANAGEMENT OF BIPOLAR DISORDER (2ND ED.)





                          ADHD                           BD
                                                         BD
                          ADHD
                  Childhood or early adolescent onset   Adolescent/adult onset
                 Childhood or early adolescent onset   Adolescent/adult onset
                                            Episodic  course,  change  from  pre-morbid
             Trait-like, no change from pre-morbid state
                                                         BD
                          ADHD
               Trait-like, no change from pre-morbid state   Episodic  course,  change  from  pre-morbid
                          ADHD
                                                         BD
                                            Adolescent/adult onset
             Childhood or early adolescent onset   state   BD
                                            state
                          ADHD
             Childhood or early adolescent onset   Adolescent/adult onset
             May be excitable but not grandiose/elated
                                            Grandiosity/elated
                          ADHD
                                            Grandiosity/elated  BD
                                            Episodic  course,  change  from  pre-morbid
             Trait-like, no change from pre-morbid state
             May be excitable but not grandiose/elated
             Childhood or early adolescent onset
                                            Adolescent/adult onset
                                            Episodic  course,  change  from  pre-morbid
             Trait-like, no change from pre-morbid state
                                            Reports  high-level  function,  not  reflecting
             Reports being unable to function
             Reports being unable to function set
             Childhood or early adolescent on
                                            Adolescent/adult onset
                                            Reports  high-level  function,  not  reflecting
                                            Episodic  course,  change  from  pre-morbid
             Trait-like, no change from pre-morbid state
                                            state
                                            behaviour
                                            Grandiosity/elated
                                            Episodic
                                            behaviour  course,  change  from  pre-morbid
             Trait-like, no change from pre-morbid state
             May be excitable but not grandiose/elated   state
                                            state
                                            Episodes of depression
                                            Grandiosity/elated
             May be excitable but not grandiose/elated
             Chronic low self-esteem   unable   to  Subjective  sense  of
             Reports being unable to
             Chronic low self-esteem function
                                            state
                                            Episodes of depression
                                            Reports  high-level  function,  not  reflecting
             May be excitable but not grandiose/elated
                                            Grandiosity/elated
                                            Tends to lack insight
                                            Reports  high-level  function,  not  reflecting
             Reports being unable to function
             Usually possesses insight
                                            behaviour
                                            Grandiosity/elated
             May be excitable but not g
             Usually possesses insight randiose/elated
             Reports being unable to function
                                            Reports  high-level
                                            Tends to lack insight  function,  not  reflecting
                                            behaviour
                                            Reduced need for sleep
             Difficulty getting off to sleep
                                            Episodes of depression
             Chronic low self-esteem
                                            Reduced need for sleep tion,  not  reflecting
                                            Reports  high-level  func
             Difficulty getting off to sleep
             Reports being unable to function
                                            behaviour
             Chronic low self-esteem
             Complains
                       of
                           being
                                            Episodes of depression  sharpened  mental
             Usually possesses insight
                                            Tends to lack insight
                                            behaviour
             Complains
                       of
             Chronic low self-esteem
                                            Episodes of depression
             Usually possesses insight
                                            Tends to lack insight
             concentrate/focus
                                            abilities
             Difficulty getting of
             Chronic low self-esteem
             concentrate/focus f to sleep
                                            Reduced need for sleep
                                            Episodes of depression
                                            abilities
                                            Tends to lack insight
             Usually possesses insight
                                            Reduced need for sleep
             Difficulty getting off to sleep
             Restless (fidgety, difficulty being still)
                                            Marked overactivity and agitation
                           being
                                         to  Subjective  sense
                                  unable
                                            Tends to lack insight  of  sharpened  mental
             Usually possesses insight
             Complains
                       of
                                            Marked overactivity and agitation
             Restless (fidgety, difficulty being still)
                                            Reduced need for sleep
             Difficulty getting off to sleep
                                  unable
                           being
                                         to  Subjective  sense  of  sharpened  mental
             Complains
                       of
             Difficulty getting off to sleep
                                            abilities
            Source:  Asherson, P  being   unable   to  Subjective  sense  of  sharpened  mental
             concentrate/focus , Young AH, Eich-Höchli D et al. Differential diagnosis, comorbidity, and treatment
                           being
                       of
                                         to  Subjective  sense  of
                                  unable
                                            Reduced need for sleep  sharpened  mental
             Complains
                                            abilities
             concentrate/focus
            Source:  Asherson, P, Young AH, Eich-Höchli D et al. Differential diagnosis, comorbidity, and treatment
                           being
                  of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality
             Complains dgety, difficulty being still)   to  Subjective  sense  of  sharpened  mental
             Restless (fi
                       of
                                  unable
                                            Marked overactivity and agitation
                                            abilities
             concentrate/focus
                  of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality
                                            Marked overactivity and agitation
             Restless (fidgety, difficulty being still)
                  disorder in adults. Current medical research and opinion. 2014;30(8):1657-1672
             concentrate/focus
                                            abilities
             Restless (fidgety, difficulty being still)
                                            Marked overactivity and agitation
                  disorder in adults. Current medical research and opinion. 2014;30(8):1657-1672
            Source:  Asherson, P, Young AH, Eich-Höchli D et al. Differential diagnosis, comorbidity, and treatment

             Restless (fidgety, difficulty being still)
            Source:  Asherson, P, Young AH, Eich-Höchli D et al. Differential diagnosis, comorbidity, and treatment
                                            Marked overactivity and agitation
                   of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality
            3.3.  Co-Morbidities
            Source:  Asherson, P, Young AH, Eich-Höchli D et al. Differential diagnosis, comorbidity, and treatment
                  of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality
            3.3.  Co-Morbidities
                  disorder in adults. Current medical research and opinion. 2014;30(8):1657-1672
                  of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality

                  disorder in adults. Current medical research and opinion. 2014;30(8):1657-1672

              Source:  Asherson, P, Young AH, Eich-Höchli D et al. Differential diagnosis, comorbidity, and treatment
                  of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality
            BD  pati  ents  may  have  psychiatric  and  medical  co-morbidities.  The  co-morbidities  cause
                  disorder in adults. Current medical research and opinion. 2014;30(8):1657-1672
            BD  patients  may  have  psychiatric  and  medical  co-morbidities.  The  co-morbidities  cause
            3.3.  Co-Morbidities

                  disorder in adults. Current medical research and opinion. 2014;30(8):1657-1672
            3.3.  Co-Morbidities
            difficulties  in  treatment  e.g.  decision  on  the  drugs  of  choice  and  consideration  of  drug

            difficulties  in  treatment  e.g.  decision  on  the  drugs  of  choice  and  consideration  of  drug
            3.3.
                   Co-Morbidities
              interactions. It also affects the prognosis of BD in terms of aggravating the course of illness,
            BD  patients  may  have  psychiatric  and  medical  co-morbidities.  The  co-morbidities  cause
            interactions. It also affects the prognosis of BD in terms of aggravating the course of illness,
            3.3.  Co-Morbidities

            BD  patients  may  have  psychiatric  and  medical  co-morbidities.  The  co-morbidities  cause
            delaying recovery, increasing risk of recurrence and suicide, and reducing QoL.
              difficulties  in  treatment  e.g.  decision  on  the  drugs  of  choice  and  consideration  of  drug
            delaying recovery, increasing risk of recurrence and suicide, and reducing QoL.
            BD  patients  may  have  psychiatric  and  medical  co-morbidities.  The  co-morbidities  cause

            difficulties  in  treatment  e.g.  decision  on  the  drugs  of  choice  and  consideration  of  drug
            interactions. It also affects the prognosis of BD in terms of aggravating the course of illness,
              BD  patients  may  have  psychiatric  and  medical  co-morbidities.  The  co-morbidities  cause
            difficulties  in  treatment  e.g.  decision  on  the  drugs  of  choice  and  consideration  of  drug
                                                                  23, level III
            The prevalence of eating disorders in BD populations ranges from 1.9% to 33.3%.
                                                                  23, level III  The
            interactions. It also affects the prognosis of BD in terms of aggravating the course of illness,
                                                                        The
            delaying recovery, increasing risk of recurrence and suicide, and reducing QoL.
            The prevalence of eating disorders in BD populations ranges from 1.9% to 33.3%.
            difficulties  in  treatment  e.g.  decision  on  the  drugs  of  choice  and  consideration  of  drug
            interactions. It also affects the prognosis of BD in terms of aggravating the course of illness,
            prevalence of co-morbid antisocial personality disorder (ASPD) in BD ranges between 4.8%
            delaying recovery, increasing risk of recurrence and suicide, and reducing QoL.
            interactions. It also affects the prognosis of BD in terms of aggravating the course of illness,
            prevalence of co-morbid antisocial personality disorder (ASPD) in BD ranges between 4.8%

            delaying recovery, increasing risk of recurrence and suicide, and reducing QoL.
              and  63%.It  is  higher  in  BD  I  (45.1%)  than  BD  II  (8.2%).  The  most  commonly  abused
                                                                        The
                                                                  23, level III
            and  63%.It  is  higher  in  BD  I  (45.1%)  than  BD  II  (8.2%).  The  most  commonly  abused
            The prevalence of eating disorders in BD populations ranges from 1.9% to 33.3%.
            delaying recovery, increasing risk of recurrence and suicide, and reducing QoL.

                                                                  23, level III
            substances in BD with ASPD are a combination of cocaine and alcohol. People with this co-
            The prevalence of eating disorders in BD populations ranges from 1.9% to 33.3%.
              prevalence of co-morbid antisocial personality disorder (ASPD) in BD ranges between 4.8%
            substances in BD with ASPD are a combination of cocaine and alcohol. People with this co-
                                                                        The
            The prevalence of eating disorders in BD populations ranges from 1.9% to 33.3%.
            morbidity have early onset of symptoms, impulsive traits, increased episodes of depression
            prevalence of co-morbid antisocial personality disorder (ASPD) in BD ranges between 4.8%
            and  63%.It  is  higher  in  BD  I  (45.1%)  than  BD  II  (8.2%).  The  most  commonly  abused
                                                                        The
                                                                  23, level III
            morbidity have early onset of symptoms, impulsive traits, increased episodes of depression
            The prevalence of eating disorders in BD populations ranges from 1.9% to 33.3%.
            prevalence of co-morbid antisocial personality disorder (ASPD) in BD ranges between 4.8%
                                                    24, level I most  commonly  abused
            and  63%.It  is  higher  in  BD  I  (45.1%)  than  BD  II  (8.2%).  The
            and mania, aggressive behaviour and high suicide attempts.
            substances in BD with ASPD are a combination of cocaine
            and mania, aggressive behaviour and high suicide attempts.and alcohol. People with this co-
            prevalence of co-morbid antisocial personality disorder (ASPD) in BD ranges between 4.8%
            and  63%.It  is  higher  in  BD  I  (45.1%)  than  BD  II  (8.2%).  The  most  commonly  abused
            substances in BD with ASPD are a combination of cocaine and alcohol. People with this co-

              and  63%.It  is  higher  in  BD  I  (45.1%)  than  BD  II  (8.2%).  The  most  commonly  abused
            morbidity have early onset of symptoms, impulsive traits, increased episodes of depression
            substances in BD with ASPD are a combination of cocaine and alcohol. People with this co-
                                           25, level II-2
            Other psychiatric co-morbidities in BD include:
            morbidity have early onset of symptoms, impulsive traits, increased episodes of depression
                                                    24, level I
            Other psychiatric co-morbidities in BD include:cide attempts.
            and mania, aggressive behaviour and high sui
            substances in BD with ASPD are a combination of cocaine and alcohol. People with this co-
            morbidity have early onset of symptoms, impulsive traits, increased episodes of depression
                drug abuse (33.5%)
            and mania, aggressive behaviour and high suicide attempts.
                                                    24, level I
                drug abuse (33.5%)

            morbidity have early onset of symptoms, impulsive traits, increased episodes of depression
                                                    24, level I
            and mania, aggressive behaviour and high suicide attempts.
                anxiety disorder (31.8%)



                                                    24, level I
                anxiety disorder (31.8%)
                                           25, level II-2
            Other psychiatric co-morbidities in BD include: 25, level II-2      24, level I            23, level III  The
            and mania, aggressive behaviour and high suicide attempts.

                borderline personality disorder (6.9%)


            Other psychiatric co-morbidities in BD include:
                                           25, level II-2
                drug abuse (33.5%)
              Other psychiatric co-morbidities in BD include:
                borderline personality disorder (6.9%)    25, level II-2

                ADHD (5.2%)

                drug abuse (33.5%)

                ADHD (5.2%)
                anxiety disorder (31.8%)
            Other psychiatric co-morbidities in BD include: 25, level II-2
                drug abuse (33.5%)
                 anxiety disorder (31.8%)

                 borderline personality disorder (6.9%)     25, level II-2
                drug abuse (33.5%)

                anxiety disorder (31.8%)
                borderline personality disorder (6.9%)

            Patients with BD may have medical co-morbidities as follows: 25, level II-2
                ADHD (5.2%)

            Patients with BD may have medical co-morbidities as follows:
                anxiety disorder (31.8%)


                borderline personality disorder (6.9%)
                ADHD (5.2%)

                 hypertension (31.1%)
                hypertension (31.1%) disorder (6.9%)
                borderline personality


                asthma (11.7%)
                ADHD (5.2%)
              Patients with BD may have medical co-morbidities as follows: 25, level II-2
                asthma (11.7%)
                ADHD (5.2%)



            Patients with BD may have medical co-morbidities as follows:
                diabetes mellitus (11%)
                                                     25, level II-2

                diabetes mellitus (11%)
                hypertension (31.1%)
              Patients with BD may have medical co-morbidities as follows: 25, level II-2
                hypertension (31.1%)
                obesity (11%)


                asthma (11.7%)
                obesity (11%)

            Patients with BD may have medical co-morbidities as follows: 25, level II-2
                hypothyroidism (11%)
                asthma (11.7%)
                hypertension (31.1%)


                hypothyroidism (11%)
                diabetes mellitus (11%)
                hypertension (31.1%)

                asthma (11.7%)
                diabetes mellitus (11%)
                migraine (5.5%)
                obesity (11%)
                asthma (11.7%)
                migraine (5.5%)
                diabetes mellitus (11%)
                obesity (11%)   is human immunodeficiency virus (HIV) infection (1%).
            Another co-morbidity                              26, level II-2

                                                              26, level II-2
            Another co-morbidity is human immunodeficiency virus (HIV) infection (1%).
                hypothyroidism (11%)
                obesity (11%)


                hypothyroidism (11%)
                   diabetes mellitus (11%)
                migraine (5.5%)
                obesity (11%)



                hypothyroidism (11%)

                migraine (5.5%)
                Another co-morbidity is human immunodeficiency virus (HIV) infection (1%). 26, level II-2
                hypothyroidism (11%)

                migraine (5.5%)

              Another co-morbidity is human immunodeficiency virus (HIV) infection (1%). 26, level II-2


                migraine (5.5%)
            Another co-morbidity is human immunodeficiency virus (HIV) infection (1%).
                                                              26, level II-2

                                                              26, level II-2
              Another co-morbidity is human immunodeficiency virus (HIV) infection (1%).









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