Page 12 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

8- Matrix.1 course content versus course k. elements:

Outcomes: Domains / Key elements
Domain:1 Domain:2 Domain:3 Domain:4
Week Topics
No.
1.1.9.1 1.1.9.2 1.1.9.3 2.2.4.1 2.4.3.1 2.5.4.1 3.1.1.1 3.1.1.2 4.1.2.1 4.2.1.1 4.3.2.1

Introduction to
1. - - √ - √ √ √ √ √ √ √
pharmacokinetics
2. Rates and orders of reactions - - √ - √ √ √ √ √ √ √
Pharmacokinetics model

3. Intravenous bolus - - √ - √ √ √ √ √ √ √
administration: one-
compartment model
Introduction to
biopharmaceutics and
4. √ √ √ √ √ - √ √ √ √ √
pharmacokinetics definitions,
Bioavailability.
Factors affecting drug
5. absorption (Physiological √ √ - √ - - √ √ √ √ √
factors)
Factors affecting drug
6. absorption (Physicochemical √ √ - √ - - √ √ √ √ √
and formulation factors)
Drug distribution and
7. √ √ - √ - - √ √ √ √ √
metabolism
Drug excretion (renal and
8. √ √ - √ √ - √ √ √ √ √
non-renal)
Pharmacokinetics of drug
absorption
9. √ √ √ - √ √ √ √ √ √ √
Oral absorption: monitoring
drug in blood/plasma
Intravenous bolus
administration: Monitoring
10. drug in urine √ √ - √ √ - √ √ √ √ √
The “amount remaining to be
excreted” method (ARE)
Continuous IV infusion
(infusion rate, true and
11. √ √ - - √ √ √ √ √ √ √
practical steady state, loading
dose)
Clearance: definition- types
12 √ √ - - √ √ √ √ √ √ √
of clearance

11