Page 136 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

❑ In highly perfused organs, such as the liver, the distribution rate is relatively high;

 For most agents, the drug in that tissue rapidly equilibrates with the drug in

plasma.

 For tissues in which the distribution rate is lower (e.g., fat), reaching

equilibrium may take much longer.

‒ So, the following compartments are present:

Central Compartment Peripheral Compartment

The peripheral compartment includes
The central compartment includes the
those organs (e.g., adipose and skeletal
well‐perfused organs and tissues
muscle) which are less well‐perfused,
(heart, blood, liver, brain and kidney)
and with which drug therefore
with which drug equilibrates rapidly.
equilibrates more slowly.

Special Compartments:

The cerebrospinal fluid (CSF) and central nervous system (CNS) is restricted by the

structure of the capillaries and pericapillary glial cells.

 Drugs also have relatively poor access to pericardial fluid, bronchial secretions

and fluid in the middle ear.

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