Page 164 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

Renal Excretion

 The kidneys filter the blood and remove waste materials (including drugs and
metabolites) from it.

• As blood flows through a kidney, some of the plasma water is filtered from it into the
nephron (the functional unit of the kidney) tubule in a process called glomerular

filtration. This filtered plasma water may contain waste materials and drugs from other

parts of the body.
• As the water moves along the tubule, additional waste substances and drugs can be
secreted into the fluid. Some drugs can be reabsorbed back into the blood during a

process called urinary reabsorption.
• After glomerular filtration, renal secretion, and urinary reabsorption are completed, the

remaining fluid is excreted from the body as urine.
 Some drugs can be reabsorbed back into the blood during a process called urinary
reabsorption (passive reabsorption).

 After glomerular filtration, renal secretion, and urinary reabsorption are completed,

the remaining fluid is excreted from the body as urine.

163