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PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

CHAPTER SUMMARY

Phase I reactions Phase II reactions

Degradative reactions Synthetic reactions
Introduction of functional groups (-OH, Conjugates phase metabolites with

-NH2, -SH, -O, -COOH) glucuronic acid, sulfate, acetyl methyl

groups

Mainly cyotosomal Cytosomal, mitochondrial, cytoplasmic

Metabolites formed may be smaller, Metabolites formed are usually larger,

polar, non-polar, active, inactive polar, water soluble & inactive

Frequently asked questions

 Mention factors affecting drug metabolism

 Compare between enzyme inhibition & enzyme induction.

 Discuss: Enterohepatic cycling

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