Page 157 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

 Enzyme inhibition may be reversible or irreversible.

 In the case of competitive enzyme inhibition, the inhibitor and drug–substrate

compete for the same active center on the enzyme.
 The drug and the inhibitor may have similar chemical structures.

 An increase in the drug (substrate) concentration may displace the inhibitor from

the enzyme and partially or fully reverse the inhibition.

 In noncompetitive enzyme inhibition, the inhibitor may inhibit the enzyme by

combining at a site on the enzyme that is different from the active site.

 In this case, enzyme inhibition depends only on the inhibitor concentration.

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