Page 3 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

Subject page

16

Introduction of Pharmacokinetics 17

Pharmacokinetic Models 30

Intravenous bolus administration 35

(One-compartment model)

Pharmacokinetics of drug absorption 48

Monitoring drug in the blood (plasma/serum) 51

or site of measurement

Intravenous bolus administration monitoring drug 56

in urine

Continuous IV infusion 62

Clearance 73

Part II (Biopharmaceutics) 79

Drug Absorption 81

Drug Distribution 130

Drug Metabolism 150

Drug Elimination 161

Nonlinear pharmacokinetics 176

Performance of drug products: in vitro–in vivo correlation 179

Pharmacogenetics 184

References 188

2