Page 78 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

 If E= 0.25 indicates that 25% of the incoming drug concentration is removed by

the organ as the drug passes through.

 Organ clearance of a drug can be defined as the product of the extraction ratio

(E) and the flow rate (Q).

Cl (organ) = Q (organ) x E (organ)

( )

Cl (organ) = Q (organ) x −

Hence, systemic clearance is often partitioned into renal (Cl r) and non-renal (Cl nr)

clearance.

Cls = Clr+ Clnr

Renal clearance (Clr) Metabolic clearance (Clm)

77