Page 76 - Interactive Theoritical Notes of Bioharmaceutics and pharamcokinetics.docx compressed

PharmD clinical pharmacy program Level 3, Semester 2 Biopharmaceutics & Pharmacokinetics (PT608(

Organ clearance

▪ Following the administration of a drug, there is a well-perfused organ (kidney or

liver) that is capable of eliminating the drug.

▪ If the organ eliminates or metabolizes some or all of the drug entering the organ,

then the drug concentration (e.g. µg/mL) in the venous blood leaving the organ (CV)

is lower than the drug concentration in the arterial blood entering the organ (CA).

= −

= QCA- QCV

= Q (CA- CV)

Where;

dA : Rate of elimination
dt
Q: Blood flow rate

C A: Arterial drug concentration

Cv: Venous drug concentration

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