Page 3 - THEALOZ DUO LEAFLET CONGRES 2021_Slide
P. 3

TIENTS WITH DR
                                  FOR PATIENTS WITH DRY EYES
                                  FOR PA
                                                Y EYES
                           TREHALOSE 3% | HYALURONIC ACID 0.15%     MEDIC  AL DEVICE
                           TREHAL
                              OSE 3% | HY
                                       CID 0.15%
                                                    MEDICAL DEVICE
                                    ONIC A
                                  AL
                                   UR
             Trehalose and hyaluronic acid tackle the Dry Eye Disease
             vicious circle at multiple points


                     HYALURONIC ACID
               ⋅ Enhances hydration and lubrication
                       of the corneal surface 1,2
                    ⋅ Improves residence time 3
                    ⋅ Reduces tear evaporation 3
                                        TEAR FILM
                                       INSTABILITY
                                        / imbalance
                                 Lipid             Flora
                                changes  Meibomian  changes        TREHALOSE
                                         Gland                     ⋅ Offers osmoprotection 4
                                       Dysfunction
                                                                   HYPOTONIC
                                                                   ⋅ Restores the osmotic balance 5
                     INFLAMMATION  Eyelid      Esterase /
                       Neurogenic  inflammation  lipase release  Tear / cell
                      inflammation               Toxins  HYPEROSMOLARITY
                      Lacrimal gland
                       stimulation
                                                        Cell damage
             TREHALOSE
   ⋅ Reduces presence of inflammation                             PRESERVATIVE-FREE
 PROTECTION, HYDRATATION AND LUBRICATION OF THE EYE,    markers in tears       ⋅ Avoids further cell damage 6
                    9,11
 FOR TREATMENT OF MODERATE TO SEVERE DRY EYE SYNDROME            TREHALOSE
                                        APOPTOSIS                ⋅ Protects proteins and lipids
                                        Conjunctiva                from denaturation 7
                                                                 ⋅ Renews cellular material
                                         Cornea                    by inducing autophagy 10

                                      TREHALOSE
                                       ⋅ Protects cells
                                        from desiccation 8







    7. Luyckx J, Baudouin C. Trehalose: an intriguing disaccharide with potential for medical application in ophthalmology. Clin Ophthalmol 2011; 5: 577-81.
    8.  Baudouin C et al. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: Proceedings of the OCEAN group meeting. The Ocular
      Surface 2013; 11(4)246-258.
    9.  Li J et al. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system.
     Molecular Vision 2012; 18: 317-329.
    10.  Zhang et al. MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse
      model of amyotrophic lateral sclerosis. Autophagy. 2014; 10(4): 588–602.   3
    11.  Fariselli C. et al. Trehalose/hyaluronate eyedrop effects on ocular surface inflammatory markers and mucin expression in dry eye patients. Clinical
      Ophthalmology 2018:12 1293–1300.
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