Page 174 - DUOKOPT BIBLIOBOOK

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KEY MESSAGES

X The study showed that both PF and PC dorzolamide/timolol were equaly effective.

X The PF formulation has a lower incidence on burning and stinging.
X There was no evidence that the addition of benzalkonium chloride provided additional
efficacy.

STRENGTHS

X A 3 month study comparing efficacy PF & DTFC.
X The study include a high number of patients 261.

X Double-masked study randomized in parallel group.

WEAKNESSES

X The study had limited potential to show how the use of PF formulations in general can
improve tolerability for patients.

MARKETING CLAIM

X Preservative-free Dorzolamide-Timolol has a similar efficacy as the preserved combi-
nation but with a better tolerance.

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