Page 81 - DUOKOPT BIBLIOBOOK

EFFICACY

INTRAOCULAR PRESSURE-LOWERING EFFECTS OF

COMMONLY USED FIXED-COMBINATION DRUGS WITH

TIMOLOL: A SYSTEMATIC REVIEW AND META-ANALYSIS

Cheng JW, et al. PLoS One. 2012;7(9):e45079.

ABSTRACT

PURPOSE: The first goal of medical therapy in glaucoma is to reduce IOP, and the fixed-combination
medications are needed to achieve sufficiently low target IOP. The aim of this systematic review and
meta-analysis is to evaluate IOP-lowering effect of the commonly used fixed-combination drugs
containing 0.5% timolol.

METHODS: Meta-analysis of 41 randomized clinical trials involving 5261 patients. The mean baseline
IOP ranged from 22.0 mmHg to 30.2 mmHg after a medicine-free washout period. Endpoints: Abso-
lute and relative values of mean diurnal IOP reduction, and the highest and lowest IOP reductions on
the diurnal IOP curve.

STUDY CRITERIA: IOP mesurements (mmHg)

RESULTS: There was no significant difference in lowering IOP when comparing Dorzolamide/Timolol
with Brinzolamide/Timolol and Brimonidine/Timolol.

Mean absolute
Group Relative reduction (%) Number of studies
reduction (mmHg)
Dorzolamide/Timolol 7.41 29.9 18
Brinzolamide/Timolol 8.33 32.7 2
Brimonidine/Timolol 6.55 28.1 4
Latanoprost/Timolol 8.85 33.9 12
Travoprost/Timolol 9.09 34.9 7
Bimatoprost/Timolol 8.40 34.3 1
Table 3: IOP mesurements

CONCLUSIONS: Dorzolamide/timolol is as efficient as brinzolamide/timolol and brimonidine/timolol
in reducing IOP.

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