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IOP-Lowering Effects of Fixed-Combination Drugs

Quality score 17 18 17 18 15

IOP* ] (SD)
Baseline Hg) (mm [mean (3.4) 27.0 (3.0) 29.0 (3.7) 27.3 (2.6) 28.7 (4.0) 27.3

or (%)
POAG OHT 92 98 91 96 100

Sex (M/F) 122/197 57/72 121/149 76/94 41/87
age
Mean (years) 61.7 64.8 66.2 65.3 68.0

Withdrawals (%) 2.8 11.6 4.8 11.8 9.2

Total no. 319 129 270 170 128

Duration Weeks Weeks 12 Weeks 812 Weeks 12 Months 12

Route 9 AM 9 AM, 96 PM PM 8 AM, 8 PM 8 PM PM 8 PM 9
crossover.
0.004%
2.0%
2.0%
Intervention Medication Travoprost/ 0.004% timolol 0.5% Dorzolamide/ timolol 0.5% Latanoprost/ 0.005% timolol 0.5% Latanoprost/ 0.005% timolol 0.5% Dorzolamide/0.5% timolol Latanoprost/ 0.005% timolol 0.5% Latanoprost/ 0.005% timolol 0.5% Travoprost/0.5% 0.03% timolol Bimatoprost/0.5% timolol deviation. CR = group;

standard parallel PG =
Centre 31 Multi 25 45 1 SD = label;

Turkey Canada pressure; open AM. 8
Location Europe, U.S. Europe U.S., Spain intraocular OL = blind; to closest

Design PG DB, PG DB, PG SB, PG DB, PG SB, IOP = single SB = measurements

Cont. [45] [46] [47] [48] [49] female; blind; doi:10.1371/journal.pone.0045079.t002

2. F = male; double values,
Table Trial 200911/01 201002/01 201007/01 201007/02 201102/01 M = DB = *Pooled

PLOS ONE | www.plosone.org 6 September 2012 | Volume 7 | Issue 9 | e45079
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