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IOP-Lowering Effects of Fixed-Combination Drugs
Relative (%) (1.33) 30.51 (0.92) 21.54 (1.24) 29.96 (1.58) 29.49 (1.43) 35.34 (1.35) 34.62 (1.34) 33.56 (1.80) 34.22 - - (4.49) 40.34 (0.97) 37.06 (0.93) 34.15 (0.92) 36.07 (0.75) 36.47 (0.73) 34.80 (0.75) 35.59 - - -
(SE) Hg) (0.33) (0.23) (0.29) (0.37) (0.38) (0.35) (0.35) (0.47) (1.04) (0.25) (0.24) (0.26) (0.20) (0.20) (0.21)
Diurnal Absolute (mm 7.56 5.30 7.02 6.91 9.40 9.00 8.75 9.00 - - 9.35 9.65 8.90 10.10 9.70 9.50 10.00 - - -
Relative (%) (1.11) 30.63 (1.57) 19.65 (1.62) 28.52 (1.85) 28.64 (1.98) 30.04 (1.32) 33.30 (1.32) 31.60 (2.26) 29.84 - - (5.24) 38.76 (1.00) 35.46 (0.92) 33.86 - (0.76) 36.50 (1.12) 35.21 - - - -
(SE) Hg) (0.30) (0.36) (0.37) (0.43) (0.48) (0.36) (0.36) (0.56) (1.18) (0.25) (0.23) (0.20) (0.30)
Lowest Absolute (mm 8.30 4.50 6.56 6.56 7.30 9.10 8.70 7.40 - - 8.72 8.90 8.50 - 9.60 9.40 - - - -
Relative (%) (1.12) 33.72 (1.62) 25.65 (1.67) 32.93 (1.82) 30.96 (1.66) 39.10 (1.35) 34.90 (1.34) 33.50 (1.76) 35.05 (2.43) 31.74 (2.67) 31.36 (4.06) 42.09 (0.93) 38.66 (0.93) 34.44 - (0.75) 36.57 (1.09) 35.27 - (2.55) 28.01 (1.81) 24.85 (2.09) 31.71
(SE) (0.48) (0.51) (1.00) (0.25)
Highest Absolute Hg) (mm (0.29) 8.70 (0.43) 6.90 (0.40) 7.89 (0.44) 7.47 11.30 (0.35) 9.10 (0.35) 8.80 10.20 (0.56) 7.30 (0.63) 7.40 10.38 10.40 (0.25) 9.30 - (0.20) 9.80 (0.30) 9.70 - (0.70) 7.73 (0.48) 6.56 (0.58) 8.88
24 22
20, 18,
points after 12 8, 10 8 8 16, 12, 14, 10, 16 20 20 20
Time (hours dosing) 4, 2, 0, 6, 2, 6, 2, 0, 6, 2, 0, 8, 4, 8 2, 0, 8 2, 0, 6, 2, 2 2 14, 12, 7 0, 7 0, 14, 12, 16, 12, 8 4, 0, 14, 12, 12 12 12
of measurement (5) Curve (6) Curve (4) Curve (4) Curve (6) Curve (3) Curve (3) Curve (6) Curve (1) (1) (3) Curve (2) Curve (2) Curve (3) Curve (3) Curve (3) Curve (3) Curve (1) (1) (1)
Type IOP IOP IOP IOP IOP IOP IOP IOP Single Single IOP IOP IOP IOP IOP IOP IOP Single Single Single
of
point measurement
End (weeks) 13 13 8 8 8 13 13 8 4 4 8 6 6 6 12 12 6 4 4 4
timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol timolol error.
Brinzolamide/0.5% Brimonidine/0.5% Brimonidine/0.5% Dorzolamide/0.5% Travoprost/0.5% Brinzolamide/0.5% Dorzolamide/0.5% Latanoprost/0.5% Brimonidine/0.5% Dorzolamide/0.5% Latanoprost/0.5% Travoprost/0.5% Dorzolamide/0.5% Latanoprost/0.5% Latanoprost/0.5% Dorzolamide/0.5% Latanoprost/0.5% Latanoprost/0.5% Travoprost/0.5% Bimatoprost/0.5% standard
Medication 1.0% 0.2% 0.2% 2.0% 0.004% 1.0% 2.0% 0.005% 0.2% 2.0% 0.005% 0.004% 2.0% 0.005% 0.005% 2.0% 0.005% 0.005% 0.004% 0.03% SE =
Cont. [37] [38] [39] [40] [41] [42] [43] [44] [45] [46] [47] [48] [49] pressure; doi:10.1371/journal.pone.0045079.t003
3. intraocular
Table Trial 200810/02 200811/01 200812/01 200904/01 200904/02 200905/01 200907/01 200910/01 200911/01 201002/01 201007/01 201007/02 201102/01 IOP =
PLOS ONE | www.plosone.org 8 September 2012 | Volume 7 | Issue 9 | e45079
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