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Figure 2. Therapeutic effects of MSCs in CIA mice. (A) A schematic to show the experiments for evaluation
of the effects of MSCs on CIA. Saline: CIA induced, transplanted with saline. MSCs: CIA induced, transplanted
with MSCs. (B) Paw thickness. (C) Clinical arthritis score for all limps. (D) Histological arthritis score.
(D) ELISA for IL-1β , IL-6, TNF-α , IL-10 and TGFβ 1 levels in inflamed joints of CIA mice, treated with MSCs
(MSCs), or without MSCs (saline). * p < 0.05. N = 5.
Scientific RepoRts | 6:28915 | DOI: 10.1038/srep28915 4
