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MSCs transplantation for osteoarthritis treatment


                                           Supporting information

                                           S1 Fig. A funnel plot of VAS, WOMAC, Lequesne, IKDC, Lysholm, and Tegner scores (tif)
                                           generated by Review Manager Version 5.0.
                                           (TIF)
                                           S2 Fig. Language edit certification (tif).
                                           (PDF)

                                           S1 File. PRISMA 2009 checklist.
                                           (DOC)


                                           Acknowledgments
                                           This research was supported by the Scientific Research Subject of the Heilongjiang Province
                                           Health Department (2012–301). The funders had no role in study design, data collection and
                                           analysis, decision to publish, or preparation of the manuscript.

                                           Author Contributions

                                           Conceptualization: MY.
                                           Data curation: LY LL.
                                           Formal analysis: LB.
                                           Funding acquisition: CL.
                                           Investigation: LY LL.

                                           Methodology: LY LL.
                                           Project administration: CL.
                                           Resources: ST.
                                           Software: LY LL.
                                           Supervision: CL.

                                           Validation: ST.
                                           Visualization: LY.
                                           Writing – original draft: MY.
                                           Writing – review & editing: CL.


                                           References
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                                               (4):535–57. https://doi.org/10.1517/14712598.2016.1145651 PMID: 26798997
                                           2.  Gupta PK, Das AK, Chullikana A, Majumdar AS. Mesenchymal stem cells for cartilage repair in osteoar-
                                               thritis. Stem Cell Res Ther. 2012; 3(4):25. https://doi.org/10.1186/scrt116 PMID: 22776206
                                           3.  Freitag J, Bates D, Boyd R, Shah K, Barnard A, Huguenin L, et al. Mesenchymal stem cell therapy in
                                               the treatment of osteoarthritis: reparative pathways, safety and efficacy-a review. BMC Musculoskelet
                                               Disord. 2016; 17:230. https://doi.org/10.1186/s12891-016-1085-9 PMID: 27229856
                                           4.  Uth K, Trifonov D. Stem cell application for osteoarthritis in the knee joint: A minireview. World J Stem
                                               Cells. 2014; 6(5):629–36. https://doi.org/10.4252/wjsc.v6.i5.629 PMID: 25426260



            PLOS ONE | https://doi.org/10.1371/journal.pone.0175449 April 27, 2017                          13 / 16
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